Dialyse aktuell 2012; 16(2): 88-98
DOI: 10.1055/s-0032-1309250
Dialyse
© Georg Thieme Verlag Stuttgart · New York

Elimination von Low-density-Lipoproteinen durch adsorptive Lipidapherese – Mechanismen und Verfahren

Elimination of low-density lipoproteins by adsorptive lipid apheresis – Mechanisms and techniques
Jörg Vienken
1   BioSciences, Fresenius Medical Care Deutschland GmbH, Bad Homburg
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
13. März 2012 (online)

Die Entfernung von LDL aus dem Plasma von Patienten mit hohem Cholesterin-gehalt mit der Lipidapherese hat sich zu einem erfolgreichen therapeutischen Verfahren entwickelt. Das Vorbild der Adsorption von LDL an Biomaterialien (Adsorberpartikel) ist die Bindung an den humanen LDL-Rezeptor. Sie verläuft über die elektrostatische Wechselwirkung mit negativ geladenen Liganden. Die Effizienz der Bindung von Proteinen (LDL, Lp(a)) an Adsorbermaterialien kann durch Variation der experimentellen Bedingungen optimiert werden. Die mit Polyanionen versehenen modernen Lipidadsorber ergeben in der klinischen Anwendung gute Ergebnisse, wobei die Adsorption aus Vollblut im Vergleich zur Adsorption aus Plasma technologische Vorteile birgt.

The removal of LDL from the plasma of patients suffering from hypercholesterolemia by means of lipid apheresis is a successful therapeutic concept. The model of LDL adsorption by biomaterials originates from research on the human LDL receptor. Binding of LDL to this receptor and to biomaterials is achieved via electrostatic interactions, namely negative charges. Binding of LDL and Lp(a) to adsorbing biomaterials can be optimized through the variation of experimental conditions. Lipidadsorbers bearing polyanions at their surface yield excellent results in clinical practice, whereby the adsorption of LDL and Lp(a) from whole blood bears technological advantages compared to an exclusive removal from plasma.

 
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