Planta Med 2012; 78 - P_71
DOI: 10.1055/s-0032-1307579

2,3-dihydroxy-4-methoxyacetophenone Isolated from Cynanchum paniculatum Attenuates Scopolamine-induced Impairment of Spatial Memory in Mice.

JB Weon 1, BH Lee 1, BR Yun 1, CJ Ma 1, 2
  • 1Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200–701, Korea.
  • 2Research Institute of Biotechnology, Kangwon National University, Chuncheon 200–701, Korea

We isolated 2,3-dihydroxy-4-methoxyacetophenone from Cynenchum paniculatum which we have previously reported as having an neuroprotective effect. The objective of this study was to investigate the cognitive-enhancing effect of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced amnesia. SCOP (1 mg/kg, i.p.) induced a learning and memory deficit measured both during and after training 2,3-dihydroxy-4-methoxyacetophenone was orally administered to amnesic mice induced by scopolamine and the mice were then evaluated using the Morris water maze test. The results showed that 2,3-dihydroxy-4-methoxyacetophenone ameliorated scopolamine- induced amnesia based on the Morris water maze test. We suggest that 2,3-dihydroxy-4-methoxyacetophenone improve cognitive function and may be helpful for the treatment of Alzheimer's disease.