Planta Med 2012; 78 - P_38
DOI: 10.1055/s-0032-1307546

Microbial Biotransformation of 5,7,2',4',5-pentahydroxyflavon-3-ol from Limonium myrianthum

A Idris 1, MM Radwan 2, 5, Z Kozhamkulova 3, A Gadetskaya 3, G Zhusupova 3, Z Abilov 3, J Williamson 1, S Ross 2, 4
  • 1Department of Medicinal Chemistry
  • 2National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University 38677 MS, USA
  • 3Al-farabi Kazakh National University, School of Chemistry, Department of Organic and Natural Products Chemistry, Kazakhstan
  • 4Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University 38677 MS, USA
  • 5Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Egypt

The genus Limonium comprises 300 species and most of them can be found in Kazakhistan. Reports of the phytochemical investigation of Limonium species from Kazakhistan had resulted in isolation of different classes of bioactive compounds mostly phenolics. Bioactive guided fractionation of Limonium myrianthum resulted in the isolation of 5,7,3',4',6'-pentahydroxyflavon-3-ol (1). The compound displayed significant antifungal activity against Candida glabrata and Candida krusei at IC50 4.44 and 9.56µg/mL respectively. Biotransformation of 1 was done by Absidia glauca for further bioactivity and resulted in the formation of two new sulfated derivatives named as 5,7,3',6'-pentahydroxyflavonol-4'-sulfate (2) and 5,7,3',6'-tetrahydroxyflavonol-8,4'-disulfate (3).

Acknowledgments: We are grateful to Dr. Bharathi Avula, for assistance with the HR-ES-IMS, and Dr. Melissa Jacob for conducting the antimicrobial testing. Z.A.K. and A.G. are grateful to the Khazakhstan government for financial support.