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DOI: 10.1055/s-0032-1307540
Antimalarials from an Unidentified Plant Pathogenic Fungus Isolated from Torreya taxifolia
As part of our program to isolate antimalarial compounds from plant pathogenic fungi, an EtOAc extract of fermentation cultures of an unidentified fungus (UM#10M) isolated from diseased leaves of the conifer Torreya taxifolia Arnott. showed potent in vitro antiplasmodial and good herbicidal activities. Bioassay-guided fractionation of the culture broth extract yielded two known cytochalasins, 19,20-epoxycytochalasin C (1) [1], 19,20-epoxycytochalasin D (2) [2], and a new analogue, 18-deoxy-19,20-epoxycytochalasin C (3) as active constituents. All three compounds showed potent antimalarial activity and phytotoxicity with no cytotoxicity against a panel of mammalian cell lines. The antimalarial activity of cytochalasins has previously been reported [3].
References: [1] Abate D, et al. (1997) Phytochemistry 44: 1443–1448. [2] Espada A, et al. (1997) Tetrahedron 53: 6485–6492. [3] Ishaka M, et al. (2000) Planta Med 66: 473–475.