Structurally Diverse and Bioactive Compounds from Plant Resources (TCM)

Chemical studies on a number of plant resources (including TCM) have led to the identification of a large array of structurally interesting and/or bioactive components [1]. A few of the compounds have been selected as lead structures for our drug discovery program, and a number of modified chemical entities with significantly improved activities were also obtained. Biological evaluation showed that some of the compounds exhibited remarkable anticancer (both cytotoxic and antiangiogenesis) and antifungal activities [2]. Several groups of anticancer and antimicrobial analogous showed very clear structure activity relationships. The research also provided good scientific background to understand the function and toxicity of some traditional Chinese medicine. Acknowledgements: Financial support of the National Natural Science Foundation (Grant No. 30630072) and National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program” (Number: 2009ZX09301–001) of the People's Republic of China are gratefully acknowledged. References: [1] Yuan T, Yang SP, et al. Organic Letters 10: 617–620. [2] Yang SP, Cai YJ, et al. J Medicinal Chemistry 51: 77–85.