Traditional Chinese Medicine (TCM), whose therapeutic efficacy has long been proved
by thousands of years of clinical usage, is an important part of public healthcare
and medicine research in China and Asian countries. Natural products derived from
TCM are appreciated for their structural and functional diversity, which allow them
to be ideal tools for the chemical biology study. However, target identification is
still a big challenge for natural products discovery with novel structures and significant
bioactivity without specific targets. Over the past few years, techniques of genomics
and proteomics, as well as tools of chemobioinformatics have been employed for the
target profiling of natural products in our lab. Some successful examples, especially
the identification and validation of Bcl-2, 5-LO, DPP-IV and falcipain 2, for anti-tumor,
anti-inflammatory, anti-diabetic and anti-microbic natural products, will be introduced
in this presentation. Acknowledgements: The work was supported by NSFC(30725045), and in part by the Scientific Foundation
of Shanghai China (09dZ1975700, 10DZ1971400). References: [1] Zhang SD, Lu WQ, et al. (2011) MedChemComm 2: 471–477.
