Neuropediatrics 2012; 43(01): 017-021
DOI: 10.1055/s-0032-1307454
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Bromide in Patients with SCN1A-Mutations Manifesting as Dravet Syndrome

Jan Lotte
1  Neuropediatric Clinic and Clinic for Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schön Klinik Vogtareuth, Germany
,
Edda Haberlandt
2  Clinical Department of Pediatrics IV, Division of Neonatology, Neuropediatrics and Inherited Metabolic Diseases, Medical University Innsbruck, Innsbruck, Austria
,
Bernd Neubauer
3  Zentrum für Kinderheilkunde und Jugendmedizin, Abteilunge für Neuropädiatrie und Sozialmedizin, Universitätsklinikum Gießen, Gießen, Germany
,
Martin Staudt
1  Neuropediatric Clinic and Clinic for Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schön Klinik Vogtareuth, Germany
4  Department of Pediatric Neurology and Developmental Medicine, University Children's Hospital, Tübingen, Germany
,
Gerhard Josef Kluger
1  Neuropediatric Clinic and Clinic for Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schön Klinik Vogtareuth, Germany
5  Paracelsus Medical University, Salzburg, Austria
› Author Affiliations
Further Information

Publication History

10 August 2011

29 December 2011

Publication Date:
19 March 2012 (online)

Abstract

We report a retrospective analysis of bromide therapy in 32 patients suffering from Dravet syndrome with SCN1A-mutations who received bromide. After 3 months of bromide treatment, 26 patients (81%) showed a relevant improvement with a reduction of seizure frequency by >50% (>75%) in 18 (12) patients (56 and 37%, respectively). After 12 months, we observed a reduction of >50% (>75%) in 15 (9) patients (47 and 28%, respectively). Long-term response was noted in 18 patients (56%). Adverse reactions were mainly mild or moderate leading to treatment termination in 5/32 patients; no aggravation was reported. We conclude that bromide holds promise in patients with SCN1A-mutations suffering from Dravet syndrome.