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Aktuelle Dermatologie 2012; 38(6): 217-228
DOI: 10.1055/s-0032-1306695
DOI: 10.1055/s-0032-1306695
Fort- und Weiterbildung
© Georg Thieme Verlag KG Stuttgart · New York
Rosazea
RosaceaWeitere Informationen
Publikationsverlauf
Publikationsdatum:
25. Mai 2012 (online)

Lernziele
Kenntnisse über:
Stadieneinteilung
Sonderformen
Triggerfaktoren
Pathogenese
Prophylaxe und Therapiemöglichkeiten
Literatur
- 1 Berg M, Lidén S. An epidemiological study of rosacea. Acta Derm Venereol. 1989; 69 419-423
- 2 Yamasaki K, Gallo R L. The molecular pathology of rosacea. J Dermatol Sci. 2009; 55 77-81
-
3 National Rosacea Society .Rosacea Review. Im Internet: http://www.rosacea.org/rr/2008/spring/article_3.php Stand: 18.07.2008
- 4 Gauwerky K, Klövekorn W, Korting H C et al. Rosacea. J Dtsch Dermatol Ges. 2009; 7 996-1003
- 5 Crawford G H, Pelle M T, James W D. Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol. 2004; 51 327-341
- 6 Lehmann P. Rosacea. Clinical features, pathogenesis and therapy. Hautarzt. 2005; 56 871-885
- 7 Jansen T, Plewig G. Clinical and histological variants of rhinophyma, including nonsurgical treatment modalities. Facial Plast Surg. 1998; 14 241-253
- 8 Ezra N, Greco J F, Haley J C et al. Gnatophyma and otophyma. J Cutan Med Surg. 2009; 13 266-272
- 9 Aloi F, Tomasini C, Soro E et al. The clinicopathologic spectrum of rhinophyma. J Am Acad Dermatol. 2000; 42 468-472
- 10 Burton J L, Pye R J, Meyrick G et al. The sebum excretion rate in rosacea. Br J Dermatol. 1975; 92 541-543
- 11 Wedi B, Kapp A. Helicobacter pylori infection in skin diseases: a critical appraisal. Am J Clin Dermatol. 2002; 3 273-282
- 12 Forton F, Germaux M A, Brasseur T et al. Demodicosis and rosacea: epidemiology and significance in daily dermatologic practice. J Am Acad Dermatol. 2005; 52 74-87
- 13 Zhao Y E, Wu L P, Peng Y et al. Retrospective analysis of the association between Demodex infestation and rosacea. Arch Dermatol. 2010; 146 896-902
- 14 Yamasaki K, di Nardo A, Bardan A et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007; 13 975-980
- 15 Sibenge S, Gawkrodger D J. Rosacea: a study of clinical patterns, blood flow, and the role of Demodex folliculorum. J Am Acad Dermatol. 1992; 26 590-593
- 16 Gomaa A H, Yaar M, Eyada M M et al. Lymphangiogenesis and angiogenesis in non-phymatous rosacea. J Cutan Pathol. 2007; 34 748-753
- 17 Brauchle M, Funk J O, Kind P et al. Ultraviolet B and H2O2 are potent inducers of vascular endothelial growth factor expression in cultured keratinocytes. J Biol Chem. 1996; 271 21 793-21 797
- 18 Bakar O, Demirçay Z, Yuksel M et al. The effect of azithromycin on reactive oxygen species in rosacea. Clin Exp Dermatol. 2007; 32 197-200
- 19 Akamatsu H, Oguchi M, Nishijima S et al. The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne. Arch Dermatol Res. 1990; 282 449-454
- 20 Yoshioka A, Miyachi Y, Imamura S et al. Anti-oxidant effects of retinoids on inflammatory skin diseases. Arch Dermatol Res. 1986; 278 177-183
- 21 Baudouin C. A new approach for better comprehension of diseases of the ocular surface. J Fr Ophtalmol. 2007; 30 239-246
- 22 Akpek E K, Merchant A, Pinar V et al. Ocular rosacea: patient characteristics and follow-up. Ophthalmology. 1997; 104 1863-1867
- 23 Quarterman M J, Johnson D W, Abele D C et al. Ocular rosacea. Signs, symptoms, and tear studies before and after treatment with doxycycline. Arch Dermatol. 1997; 133 49-54
- 24 Plewig G. Akne und Rosazea.. In: Braun-Falco O, Plewig G, Wolff H, et al., Hrsg Dermatologie und Venerologie.. 5. Aufl. Heidelberg, Berlin: Springer; 2005
- 25 Plewig G, Jansen T, Kligman A M. Pyoderma faciale. A review and report of 20 additional cases: is it rosacea?. Arch Dermatol. 1992; 128 1611-1617
- 26 Jansen T, Plewig G, Kligman A M. Diagnosis and treatment of rosacea fulminans. Dermatology. 1994; 188 251-254
- 27 Culp B, Scheinfeld N. Rosacea: A Review. P T. 2009; 34 38-45
- 28 Helm K F, Menz J, Gibson L E et al. A clinical and histopathologic study of granulomatous rosacea. J Am Acad Dermatol. 1991; 25 1038-1043
- 29 Meykadeh N, Meiss F, Marsch W C et al. Steroid-aggravated rosacea: successful therapy with pimecrolimus. Hautarzt. 2007; 58 338-342
- 30 Rathi S K, Kumrah L. Topical corticosteroid-induced rosacea-like dermatitis: a clinical study of 110 cases. Indian J Dermatol Venereol Leprol. 2011; 77 42-46
- 31 Lamparter J, Kottler U, Cursiefen C et al. Morbus Morbihan: A rare cause of edematous swelling of the eyelids. Ophthalmologe. 2010; 107 553-557
- 32 Nagasaka T, Koyama T, Matsumura K et al. Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis. Clin Exp Dermatol. 2008; 33 764-767
- 33 Jansen T, Regele D, Schirren C G et al. Persistent erythema and edema of the face associated with rosacea and lymph vessel dysplasia. Hautarzt. 1998; 49 932-935
- 34 Drolet B, Paller A S. Childhood rosacea. Pediatr Dermatol. 1992; 9 22-26
- 35 Chamaillard M, Mortemousque B, Boralevi F et al. Cutaneous and ocular signs of childhood rosacea. Arch Dermatol. 2008; 144 167-171
- 36 Hong E, Fischer G. Childhood ocular rosacea: considerations for diagnosis and treatment. Australas J Dermatol. 2009; 50 272-275
- 37 Bostanci O, Borelli C, Schaller M. Treatment of extrafacial rosacea with low-dose isotretinoin. Acta Derm Venereol. 2010; 90 409-410
- 38 Pereira T M, Vieira A P, Basto A S. Rosacea with extensive extrafacial lesions. Int J Dermatol. 2008; 47 52-55
- 39 Yentzer B A, Fleischer Jr A B. Changes in rosacea comorbidities and treatment utilization over time. J Drugs Dermatol. 2010; 9 1402-1406
- 40 Gollnick H, Blume-Peytavi U, Szabó E L et al. Systemic isotretinoin in the treatment of rosacea – doxycycline- and placebo-controlled, randomized clinical study. J Dtsch Dermatol Ges. 2010; 8 505-515
- 41 van Zuuren E J, Kramer S, Carter B et al. Interventions for rosacea. Cochrane Database Syst Rev. 2011; 3 CD003262
- 42 Sobottka A, Lehmann P. Rosacea 2009: new advances in pathophysiology, clinical staging and therapeutic strategies. Hautarzt. 2009; 60 999-1009
- 43 Madsen J T, Thormann J, Kerre S et al. Allergic contact dermatitis to topical metronidazole – 3 cases. Contact Dermatitis. 2007; 56 364-366
- 44 Mastrofrancesco A, Ottaviani M, Aspite N et al. Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. Exp Dermatol. 2010; 19 813-820
- 45 Elewski B E, Fleischer Jr A B, Pariser D M. A comparison of 15 % azelaic acid gel and 0.75 % metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. Arch Dermatol. 2003; 139 1444-1450
- 46 Frampton J E, Wagstaff A J. Azelaic acid 15 % gel: in the treatment of papulopustular rosacea. Am J Clin Dermatol. 2004; 5 57-64
- 47 Liu R H, Smith M K, Basta S A et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006; 142 1047-1052
- 48 Torok H M, Webster G, Dunlap F E et al. Combination sodium sulfacetamide 10 % and sulfur 5 % cream with sunscreens versus metronidazole 0.75 % cream for rosacea. Cutis. 2005; 75 357-363
- 49 Koçak M, Yağli S, Vahapoğlu G et al. Permethrin 5 % cream versus metronidazole 0.75 % gel for the treatment of papulopustular rosacea. A randomized double-blind placebo-controlled study. Dermatology. 2002; 205 265-270
- 50 Goldman D. Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report. J Am Acad Dermatol. 2001; 44 995-998
- 51 Bhat Y J, Manzoor S, Qayoom S. Steroid-induced rosacea: a clinical study of 200 patients. Indian J Dermatol. 2011; 56 30-32
- 52 Breneman D, Savin R, VandePol C et al. Double-blind, randomized, vehicle-controlled clinical trial of once-daily benzoyl peroxide/clindamycin topical gel in the treatment of patients with moderate to severe rosacea. Int J Dermatol. 2004; 43 381-387
- 53 Korting H C, Schöllmann C. Current topical and systemic approaches to treatment of rosacea. J Eur Acad Dermatol Venereol. 2009; 23 876-882
- 54 Altinyazar H C, Koca R, Tekin N S et al. Adapalene vs. metronidazole gel for the treatment of rosacea. Int J Dermatol. 2005; 44 252-255
- 55 Goldgar C, Keahey D J, Houchins J. Treatment options for acne rosacea. Am Fam Physician. 2009; 80 461-468
- 56 Monk E, Shalita A, Siegel D. Clinical applications of non-antimicrobial tetracyclines in dermatology. Pharmacol Res. 2011; 63 130-145
- 57 Alvarenga L S, Mannis M J. Ocular rosacea. Ocul Surf. 2005; 3 41-58
- 58 Korting H C, Schöllmann C. Tetracycline actions relevant to rosacea treatment. Skin Pharmacol Physiol. 2009; 22 287-294
- 59 Iovieno A, Lambiase A, Micera A et al. In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis. Eur J Ophthalmol. 2009; 19 708-716
- 60 Baldwin H E. Systemic therapy for rosacea. Skin Therapy Lett. 2007; 12 1-5, 9
- 61 Pfeffer I, Borelli C, Zierhut M, Schaller M. Treatment of ocular rosacea with 40 mg doxycycline in a slow release form. J Dtsch Dermatol Ges. 2011; 9 904-907
- 62 Del R osso. Anti-inflamatory dose doxycycline in the treatment of rosacea. J Drugs Dermatol. 2009; 8 664-668
- 63 Akhyani M, Ehsani A H, Ghiasi M et al. Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial. Int J Dermatol. 2008; 47 284-288
- 64 Guilhou J J, Guilhou E, Malbos S et al. [Metronidazole therapy in rosacea (author's transl)]. Ann Dermatol Venereol. 1979; 106 127-129
- 65 Saihan E M, Burton J L. A double-blind trial of metronidazole versus oxytetracycline therapy for rosacea. Br J Dermatol. 1980; 102 443-445
- 66 Nikolowski J, Plewig G. Oral treatment of rosacea with 13-cis-retinoic acid. Hautarzt. 1981; 32 575-584
- 67 Jansen T, Plewig G. Rosacea: classification and treatment. J R Soc Med. 1997; 90 144-150
- 68 Shanler S D, Ondo A L. Successful treatment of the erythema and flushing of rosacea using a topically applied selective alpha1-adrenergic receptor agonist, oxymetazoline. Arch Dermatol. 2007; 143 1369-1371
- 69 Kim J H, Oh Y S, Ji J H et al. Rosacea (erythematotelangiectatic type) effectively improved by topical xylometazoline. J Dermatol. 2011; 38 510-513
- 70 Rørdam O M, Guldbakke K. Rhinophyma: big problem, simple solution. Acta Derm Venereol. 2011; 91 188-189
- 71 Moreira A, Leite I, Guedes R et al. Surgical treatment of rhinophyma using carbon dioxide (CO2) laser and pulsed dye laser (PDL). J Cosmet Laser Ther. 2010; 12 73-76
- 72 Kempiak S J, Lee P W, Pelle M T. Rhinophyma treated with cryosurgery. Dermatol Surg. 2009; 35 543-545
Prof. Dr. med. Martin Schaller
Universitäts-Hautklinik
Liebermeisterstr. 25
72076 Tübingen
eMail: Martin.Schaller@med.uni-tuebingen.de