Int J Sports Med 2012; 33(07): 525-530
DOI: 10.1055/s-0032-1306325
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Exercise Intervention May Prevent Depression

S.-B. He
1  Department of Neurology, Zhoushan Hospital, Zhoushan, China
,
W.-G. Tang
1  Department of Neurology, Zhoushan Hospital, Zhoushan, China
,
W.-J. Tang
2  Department of Neurology, Wenzhou Medical College, Wenzhou, China
,
X.-L. Kao
1  Department of Neurology, Zhoushan Hospital, Zhoushan, China
,
C.-G. Zhang
2  Department of Neurology, Wenzhou Medical College, Wenzhou, China
,
X.-T. Wong
2  Department of Neurology, Wenzhou Medical College, Wenzhou, China
› Author Affiliations
Further Information

Publication History



accepted after revision 13 February 2012

Publication Date:
13 April 2012 (eFirst)

Abstract

Physical activity is an effective component of depression management. However, the mechanisms by which exercise affects behavioral disorders remain unclear. The present study was conducted to investigate mechanisms by which voluntary exercise ameliorates depression. Plasma cortisol levels and hippocampal monoamine neurotransmitters were measured. Chronic mild stress (CMS) was used to induce depression in a rat model. The rats were allowed to swim for 10 weeks as part of their exercise treatment. Depressive behavior was analyzed using an open-field test and a sucrose consumption test before and after exercise. Serum cortisol levels were measured by radioimmunoassay. The concentrations of monoamine neurotransmitters in the hippocampus were determined using high-performance liquid chromatography with electrochemical detection. The CMS rats showed behavioral improvement after exercise. Compared with the control, serum cortisol levels were significantly increased by CMS. The serotonin, dopamine, and norepinephrine levels in the hippocampi were significantly increased by exercise. These findings indicate that exercise reverses and prevents the decrease in serotonin and noradrenaline, and restores dopamine in the CMS model.