Zentralblatt für Chirurgie, Table of Contents Zentralbl Chir 2012; 137(01): 1-3DOI: 10.1055/s-0032-1305957 Aktuelle Chirurgie Georg Thieme Verlag KG Stuttgart · New YorkTranslationale Onkologie – Effiziente Umsetzung onkologischer Grundlagenforschung Christoph Heining , Christof von Kalle Recommend Article Abstract Full Text References Literatur 1 Druker BJ, Talpaz M, Resta DJ et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-1037 2 Heinrich MC, Blanke CD, Druker BJ et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 2002; 20: 1692-1703 3 Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-2139 4 Fong PC, Boss DS, Yap TA et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 123-134 5 Kwak EL, Bang YJ, Camidge DR et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010; 363: 1693-1703 6 Flaherty KT, Puzanov I, Kim KB et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010; 363: 809-819 7 Poste G. Bring on the biomarkers. Nature 2011; 469: 156-157 8 Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science 2011; 331: 1553-1558