Postoperative Ableitungen von Lokalen Feldpotentialen bei Patienten mit Bewegungsstörungen

Deep brain stimulation (DBS) has become an established treatment in patients with movement disorders. However, the exact mechanism of action is still not completely understood. Functional neurosurgery has provided the unique opportunity to directly record neuronal activity from deep brain structures. In my talk I will present data from local field potential recordings in patients undergoing DBS for Parkinson's disease, dystonia and Tourette syndrome to show that abnormal oscillatory activity can be found in the cortex–basal ganglia loop in those patients. This abnormal activity is disease-specific, it is correlated with the abnormal movements and can be modulated by drugs as well as DBS. Most evidence comes from recordings in PD patients, where enhanced oscillatory activity in the beta (~20 Hz) frequency band has been established as a hallmark of PD and is modulated by levodopa therapy and DBS in parallel with clinical improvement in bradykinesia and rigidity. Suppression of abnormal oscillatory activity as a general mechanism of DBS may offer an explanation for the therapeutic effects of DBS in patients with different movement disorders.