Int J Sports Med 2012; 33(07): 572-579
DOI: 10.1055/s-0031-1301318
Clinical Sciences
© Georg Thieme Verlag KG Stuttgart · New York

Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats

L. Lin
1  Hunan Normal University, College of Physical Education, Changsha, China
,
W. M. Cai
1  Hunan Normal University, College of Physical Education, Changsha, China
,
C. J. Qin
1  Hunan Normal University, College of Physical Education, Changsha, China
,
L. C. Miao
2  Central Hospital of Shaoyang, Shaoyang, China
,
L. T. Yun
2  Central Hospital of Shaoyang, Shaoyang, China
,
Y. Hua
2  Central Hospital of Shaoyang, Shaoyang, China
,
L. Weilin
1  Hunan Normal University, College of Physical Education, Changsha, China
› Author Affiliations
Further Information

Publication History



accepted after revision 14 December 2011

Publication Date:
04 May 2012 (online)

Abstract

Obstructive jaundice is a common surgical disease and a variety of end-stage severe liver injuries still lack effective treatments. Compared to traditional liver transplantation therapy, herbal treatment is noninvasive and has fewer side effects. Research results have shown that a modified major decoction of bupleurum can reduce the toxic reaction of obstructive jaundice, even though the mechanism is unclear. A period of chronic exercise training can significantly reduce TLR4 expression in mononuclear cells and the secretion of inflammatory cell factors. Our study administered a modified major decoction of bupleurum in combination with exercise in rats with obstructive jaundice and the results indicated that applying a major bupleurum decoction in combination with moderately intense aerobic exercise showed a beneficial effect on adjusting the expression of liver inflammatory cytokines, which thus improved immunity and finally reduced the liver injury of rats with obstructive jaundice.