Synthesis, characterization and cytotoxic activity of new salicylaldehyde benzoylhydrazone derivatives as potential anti-proliferative agents

Abstract

Three new hydrazones, derivatives of salicylaldehyde benzoylhydrazone, were synthesized as potential anti-proliferative compounds. The structure of the new compounds was characterized by elemental and thermo-gravimetric analyses, IR, ¹H and ¹³C-NMR spectroscopy and quantum chemical calculations. The cytotoxic effects of new hydrazones were examined on a wide spectrum of human tumor cell lines. The obtained results revealed that all compounds proved to be equipotent or more active than cisplatin, and far more active than another utilized anticancer drug, melphalan. On the basis of IC₅₀ values the compound 3-methoxy-salicylaldehyde isonicotinoylhydrazone (mSIH) was found to be the most active cytotoxic agent at all cell lines.

Key words

Anticancer agents - Aroylhydrazones - Density functional theory calculations - MTT-dye reduction assay - Salicylaldehyde benzoyl-hydrazone derivatives

• References

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