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Arzneimittelforschung 2002; 52(6): 462-467
DOI: 10.1055/s-0031-1299915
Analgesics · Antiphlogistics · Antirheumatic Drugs
Editio Cantor Verlag Aulendorf (Germany)

Evaluation of the Analgesic and Anti-inflammatory Activities of Some Thiazolo[4,5-d]pyrimidines

Authors

  • Ayla Balkan

    a   Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey

  • Zafer Gören

    b   Marmara University, Department of Pharmacology and Clinical Pharmacology, The School of Medicine, Istanbul, Turkey

  • Hüsne Urgun

    a   Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey

  • Ünsal Çalιş

    a   Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey

  • A. Nur Çakar

    c   Hacettepe University, Faculty of Medicine, Department of Histology and Embriyology, Ankara, Turkey

  • Pergin Atilla

    c   Hacettepe University, Faculty of Medicine, Department of Histology and Embriyology, Ankara, Turkey

  • Tayfun Uzbay

    d   Military medical Academy of Gülhane, Department of Pharmacology, Etlik, Ankara, Turkey
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Publikationsverlauf

Publikationsdatum:
26. Dezember 2011 (online)

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Summary

Some thiazolo[4,5-d]pyrimidine-7(6H)-one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 31. The most active members of the series were investigated for their ED50 values and ulcerogenic potential.

Zusammenfassung

Thiazolo[4,5-d]pyrimidine als potentielle analgetische und entzündungshemmende Wirkstoffe

Einige Thiazolo[4,5-d]pyrimidin-7(6H)-on-Derivative wurden auf ihre analgetische und entzündungshemmende Aktivität in vitro untersucht. Die Aktivität der Verbindungen wurde mit Acetylsalicylsäure und Phenylbutazon verglichen. Im Pfotenödem-Test zeigten die Substanzen 3b und 3h die beste Wirkung. Die höchsten analgetischen Aktivitäten wurden bei Substanz 2a und 3l beobachtet. Die ED 50-Werte der aktiven Substanzen und ihre ulzerogene Wirkung wurde untersucht.

Key words

Anti-inflammatories, non-steroidal - Thiazolo[4,5-d]pyrimidines, analgesic activity, anti-inflammatory activity