COL11A1 Gene is Associated with Limbus Vertebra in Gymnasts

K. Koyama; K. Nakazato; S Min; K. Gushiken; Y. Hatakeda; K. Seo; K. Hiranuma

doi:10.1055/s-0031-1299752

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2012; 33(07): 586-590
DOI: 10.1055/s-0031-1299752

Genetics & Molecular Biology

COL11A1 Gene is Associated with Limbus Vertebra in Gymnasts

Authors

K. Koyama

¹Department of Judotherapy, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan

⁴Graduate School of Health and Sport Sciences, Nippon Sport Science University, Tokyo, Japan
K. Nakazato

²Department of Exercise Physiology, Graduate School of Health and Sport Sciences, Nippon Sport Science University, Tokyo, Japan
S Min

²Department of Exercise Physiology, Graduate School of Health and Sport Sciences, Nippon Sport Science University, Tokyo, Japan
K. Gushiken

³Sports Methodology(Gymnastic), Nippon Sport Science University, Tokyo, Japan
Y. Hatakeda

³Sports Methodology(Gymnastic), Nippon Sport Science University, Tokyo, Japan
K. Seo

³Sports Methodology(Gymnastic), Nippon Sport Science University, Tokyo, Japan
K. Hiranuma

⁴Graduate School of Health and Sport Sciences, Nippon Sport Science University, Tokyo, Japan

Abstract

Several studies have shown higher frequencies of radiological abnormalities among gymnasts. Recently, the gene encoding the α1 chain of type XI collagen, (COL11A1) (rs 1676486), was associated with lumbar disc herniation in the Japanese population. We hypothesized that there was a significant relationship between abnormal magnetic resonance imaging (MRI) findings of the lumbar spine and the COL11A1 4603C/T gene polymorphism in collegiate gymnasts. Our study participants included 103 Japanese collegiate gymnasts (70 men and 33 women). Radiological abnormalities were evaluated using T1- and T2-weighted MRI. Genotyping for COL11A1 was performed for all the participants. By using logistic regression analysis, we observed significant associations between limbus vertebra and age (adjusted odds ratio=0.51, 95% confidence interval: 0.27–0.96), sporting experience (adjusted odds ratio=1.49, 95% confidence interval: 1.14–1.94), and a TT genotype (adjusted odds ratio=7.83, 95% confidence interval: 1.33–46.03). We conclude that a TT genotype of COL11A1 polymorphism may be a significant risk factor for limbus vertebra in Japanese collegiate gymnasts.

Key words

magnetic resonance imaging - radiological abnormalities - polymorphism

Full Text

References

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