Polyphenolic Acetylcholinesterase Inhibitors from Hopea chinensis

Abstract

Bioassay-guided investigation of the stem bark of Hopea chinensis led to the isolation of two new polyphenols, hopeachinols C (1) and D (2), together with ten known compounds (3–12). Compounds 1 and 2 were determined by extensive analysis of spectroscopic data and computational methods. All of these phytochemicals were tested for acetylcholinesterase inhibitory activity, and five resveratrol-derived compounds (1 and 7–10) exhibited significant activity with their IC₅₀ values ranging from 4.81 to 11.71 µM.

Key words

Hopea chinensis Hand.-Mazz. - Dipterocarpaceae - acetylcholinesterase inhibitor - polyphenol - structure elucidation

• References

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