Leishmanicidal Compounds from the Fruits of Piper longum

Abstract

One new alkaloid amide, piperlongumide (1) [N-isobutyl-19-(3′,4′-methylenedioxyphenyl)-2E,4E nonadecadienamide], and six known compounds with leishmanicidal activity against promastigotes and axenic amastigotes of Leishmania donovani were isolated from the n-hexane fraction of the fruits of Piper longum. The structure of 1 was elucidated by spectroscopic evidences.

Key words

Piper longum - Piperaceae - piperlongumide - Leishmania donovani - promastigotes - axenic amastigotes

• References

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