Semin Thromb Hemost 2011; 37(8): 955-960
DOI: 10.1055/s-0031-1297374
© Thieme Medical Publishers

Factor V Leiden Mutation in Severe Infection and Sepsis

Marcel Levi1 , Marcel Schouten1 , 2 , 3 , Cees van't Veer1 , 2 , 3 , Tom van der Poll1 , 2 , 3
  • 1Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
  • 2Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, The Netherlands
  • 3Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Further Information

Publication History

Publication Date:
23 December 2011 (online)


In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.


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Marcel Levi, M.D. 

Department of Medicine (F-4), Academic Medical Center, University of Amsterdam

Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands