DMW – Klinischer Fortschritt, Table of Contents Dtsch Med Wochenschr 2011; 136(48): 2483-2485DOI: 10.1055/s-0031-1297272 Nephrologie | CommentaryNephrologie© Georg Thieme Verlag KG Stuttgart · New YorkStörungen des Wasser- und ElektrolythaushaltsDisorders of fluid and electrolyte balanceR. Kettritz1 , 2 , F. C. Luft2 1Nephrologie und Internistische Intensivmedizin, Universitätsmedizin Charite Virchow-Klinikum Berlin 2Experimental and Clinical Research Center (ECRC), Campus Buch, Berlin Recommend Article Abstract Buy Article Corrected by:Störungen des Wasser- und ElektrolythaushaltsDtsch Med Wochenschr 2012; 137(05): 229-229DOI: 10.1055/s-0031-1297280 Schlüsselwörter Hyponatriämie - Tolvaptan - Desmopressin - Natriumkanäle - Durstregulation Keywords hyponatremia - tolvaptan - desmopressin - natrium channels - regulation of thirst Full Text References Literatur 1 Berl T, Quittnat-Pelletier F, Verbalis J G. et al . Oral tolvaptan is safe and effective in chronic hyponatremia. J Am Soc Nephrol. 2010; 21 705-712 2 Berl T, Rastegar A. A patient with severe hyponatremia and hypokalemia: osmotic demyelination following potassium repletion. Am J Kidney Dis. 2010; 55 742-748 3 Einhorn L M, Zhan M, Hsu V D. et al . The frequency of hyperkalemia and its significance in chronic kidney disease. Arch Intern Med. 2009; 169 1156-1162 4 Hiyama T Y, Matsuda S, Fujikawa A. et al . Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia. Neuron. 2010; 66 508-522 5 Konstam M A, Gheorghiade M, Burnett J C Jr. et al . Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA. 2007; 297 1319-1331 6 Korgaonkar S, Tilea A, Gillespie B W. et al . Serum potassium and outcomes in CKD: insights from the RRI-CKD cohort study. Clin J Am Soc Nephrol. 2010; 5 762-769 7 Perianayagam A, Sterns R H, Silver S M. et al . DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia. Clin J Am Soc Nephrol. 2008; 3 331-336 8 Schrier R W, Gross P, Gheorghiade M. et al . Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med. 2006; 355 2099-2112 9 Suzuki H, Sugimura Y, Iwama S. et al . Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. J Am Soc Nephrol. 2010; 21 2090-2098 10 Tian W, Fu Y, Garcia-Elias A. et al . A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A. 2009; 106 14034-14039 11 Wang C J, Lin Y N, Huang S W. et al . Low dose oral desmopressin for nocturnal polyuria in patients with benign prostatic hyperplasia: a double-blind, placebo controlled, randomized study. J Urol. 2011; 185 219-223 Prof. Dr. med. Ralph Kettritz Universitätsmedizin BerlinCharité Campus BuchExperimental and Clinical Research Center Lindenberger Weg 80 13125 Berlin Phone: 030/450540002 Fax: 030/450540900 Email: kettritz@charite.de