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Arzneimittelforschung 2006; 56(8): 593-599
DOI: 10.1055/s-0031-1296757
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis of Some Novel Sulfur Containing Triazolothienopyrimidines and Biscompounds as Possible Antitumor and Radioprotective Agents

Helmy I. Heiba
1   Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Fatma A. Ragab
2   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
,
Eman Noaman
3   Department of Radiation Biology, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Moustafa M. Ghorab
1   Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Marwa Galal
1   Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
22 December 2011 (online)

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Summary

The syntheses of novel 1,2,4-triazolothi-enopyrimidine derivatives (4a,b), thiourea derivatives (5-8) and biscompounds having a thieno[2,3-d]pyrimidine nucleus (13-16) utilizing the 2-isothiocyanato derivatives 2a,b are reported. The structures of these compounds were confirmed by microanalysis, IR, 1H-NMR and mass spectrometry. Preliminary biological studies of some synthesized compounds showed promising antitumor and radioprotective activities.

Zusammenfassung

Synthese neuer Schwefel enthaltender Triazolothienopyrimidine und Bisverbindungen als Zytostatika und radioprotek-tive Substanzen

In der vorliegenden Studie wurden neue 1,2,4-Triazolothienopyrimidine (4a,b), Thiourea-Derivate (5-8) sowie Bisverbindungen mit einem Thieno[2,3-d]pyrimidin-Kern (13-16) unter Verwendung der 2-Isothiocyanato-Derivate 2a,b synthetisiert. Die Strukturen dieser Verbindungen wurden mittels Mikroanalyse, IR, 1H-NMR und Massenspektrometrie bestimmt. Vorläufige biologische Studien ergaben für einige dieser Verbindungen gute zytostatische und radioprotektive Wirkung.

Key words

Antitumor agents - Radioprotective agents - Thieno[2,3-d]pyrimidines, antitumor and radiopro-tectice action, synthesis