Arzneimittelforschung 2006; 56(6): 405-413
DOI: 10.1055/s-0031-1296742
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Novel Antitumor and Radioprotective Sulfonamides Containing Pyrrolo[2,3-d]pyrimidines

Moustafa M. Ghorab
1  Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Eman Noaman
2  Department of Radiation Biology, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Magda M. F. Ismail
3  Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
,
Helmy I. Heiba
1  Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Yousry A. Ammar
4  Department of Organic Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
,
Marwa Y. Sayed
1  Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
22 December 2011 (online)

Summary

Several sulfonamides having pyrrole (5a-c, 8, 11b-19, 23, 24), pyrrolo[2,3-d] pyrimidine (6, 7, 10, 20, 21, 25) and pyrrolo[2,3-b]pyridine (22) were synthesized and evaluated for their antitumor and radioprotective activities. The structure of the synthesized compounds was elucidated by elemental analyses and spectral data. Compounds 5a, 16, 17, 19, and 23 displayed more potent antitumor activities than the reference drug, doxorubicin. On the other hand compounds 19, 23 and 25 exhibited radioprotective activities.

Zusammenfassung

Neue Pyrrolo[2,3-d]pyrimidin-Sulfonamide mit Antitumor- und radioprotektiver Wirkung

Mehrere Sulfonamide mit Pyrrol-(5a-c, 8, 11b-19, 23, 24), Pyrrolo[2,3-d] pyrimidin- (6, 7, 10, 20, 21, 25) und Pyrrolo[2,3-b]pyridin-Resten wurden synthetisiert und auf Antitumor- und radioprotektive Aktivität untersucht. Die Struktur der neu synthetisierten Verbindungen wurde mittels Elementaranalyse und Spektraldaten bestimmt. Die Verbindung 5a, 16, 17, 19, und 23 zeigten eine stärkere Antitumor-Aktivität als die Referenz-substanz Doxorubicin. Die Verbindungen 19, 23 und 25 hatten radioprotektive Wirkung.