Arzneimittelforschung 2008; 58(10): 505-509
DOI: 10.1055/s-0031-1296549
Antihypertensives
Editio Cantor Verlag Aulendorf (Germany)

Efficacy and Safety of Benidipine Therapy of Essential Hypertension in Elderly Chinese Patients

Hai-Ya Wang
1   Geriatric Department Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, The People’s Republic of China
,
Chuan-Fu Wang
2   Geriatric Department Hua Dong Hospital, Fudan University Shanghai, The People’s Republic of China
,
Zhi-Hong Pan
3   Geriatric Department Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, The People’s Republic of China
,
Han Wu
4   Geriatric Department, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, The People’s Republic of China
,
Yuan Zhong
5   Geriatric Department, Shanghai No.6 People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, The People’s Republic of China
,
Xian-Chuan Chen
6   Geriatric Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, The People’s Republic of China
,
Shu-Hua Zhang
7   Geriatric Department, Shanghai Tenth People’s Hospital affiliated to Tongji University, Shanghai, The People’s Republic of China
,
Hua Zhang
8   Geriatric Department Shanghai Dongfang Hospital, Shanghai, The People’s Republic of China
,
Ning-Yuan Fang
1   Geriatric Department Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, The People’s Republic of China
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Publikationsdatum:
19. Dezember 2011 (online)

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Abstract

Background:

Benidipine (CAS 105979-17-7) is a dihydropyridine calcium channel blocker used in the treatment of hypertension and angina pectoris.

Objective:

To examine the efficacy and safety of therapy with benidipine in elderly hypertensive patients.

Methods:

Chinese patients > 60 years of age with mild to moderate essential hypertension were enrolled. The patients were prescribed benidipine at the dose of 8 mg once daily for 12 weeks. Detailed laboratory examinations and 24-h ambulatory blood pressure monitoring were performed before and after the treatment.

Results:

One hundred and sixty-four of the 180 patients enrolled completed the 12-week active treatment phase. Sitting systolic blood pressure (SBP) and diastolic blood pressure (DBP) reductions at the end of treatment were 21.50 ± 12.83 and 10.60 ± 8.04 mmHg, respectively; the proportion of patients showing a good treatment response was 95.1% for SBP and 96.9% for DBP. Benidipine significantly reduced the mean 24-h ambulatory blood pressure (p<0.001 vs. baseline) exhibiting smooth, sustained effects and high trough-to-peak ratios (T/P ratio) (0.87 for SBP and 0.72 for DBP). Moreover, benidipine significantly reduced the systolic morning blood pressure surge and urinary albumin, and it was well tolerated. No serious adverse events were noted.

Conclusion:

Benidipine was well tolerated and effective in elderly Chinese patients with essential hypertension.