Arzneimittelforschung 2008; 58(7): 328-335
DOI: 10.1055/s-0031-1296515
Antiemetics · Gastrointestinal Drugs · Urologic Drugs
Editio Cantor Verlag Aulendorf (Germany)

Intravesical Glycosaminoglycan Replenishment with Chondroitin Sulphate in Chronic Forms of Cystitis

A multi-national, multi-centre, prospective observational clinical trial
Jørgen Nordling
1  Copenhagen University Hospital, Herlev, Denmark
,
Arndt van Ophoven
2  Münster University Hospital, Münster, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
15 December 2011 (online)

Abstract

Effectiveness, safety, and tolerability of instillation therapy with chondroitin sulphate (CAS 9082-07-9, Gepan® instill) was investigated in a non-interventional study. 286 patients with clinically diagnosed chronic forms of cystitis, such as bladder pain syndrome/interstitial cystitis, radiation cystitis, overactive bladder syndrome and chronically-recurring cystitis were included. The course of symptoms was documented over 8 instillations at maximum, covering a period of approximately three months. All main symptoms of chronic cystitis declined consistently and statistically significantly (p < 0.0001). Both daytime and nighttime micturition frequencies as well as the score levels of urgency and pain declined significantly during the course of treatment. The functional bladder capacity as indicated by the volume of first morning voiding increased from 157.9 ml ± 7.5 to 186.7 ml ± 6.9 (mean ± SE; p < 0.0001). The level of urgency decreased from 6.8 ± 0.1 to 3.4 ± 0.2 (mean ± SE; numerical rating scale (11-point box scale); p < 0.0001) and nocturia decreased from 4.0 ± 0.2 to 2.1 ± 0.1 times (mean ± SE; p < 0.0001).

Chondroitin sulphate instillation was effective and well tolerated in the therapy of chronic forms of cystitis associated with a possible GAG layer deficit (GAG layer: mainly composed of the glycosaminoglycans chondroitin sulphate, dermatan sulphate and heparan sulphate), but the results need to be confirmed in a controlled study.