Arzneimittelforschung 2008; 58(6): 265-268
DOI: 10.1055/s-0031-1296505
CNS-active Drugs · Hypnotics · Psychotropics · Sedatives
Editio Cantor Verlag Aulendorf (Germany)

Validation of the APP23 Transgenic Mouse Model of Alzheimer’s Disease through Evaluation of Risperidone Treatment on Aggressive Behaviour

Ellen Vloeberghs
1   Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
Katrien Coen
1   Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
Debby Van Dam
1   Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
Peter Paul De Deyn
1   Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
2   Department of Neurology – Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium
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15. Dezember 2011 (online)


Valid animal models are indispensable in the drug discovery pipeline for dementia. Transgenic APP23 mice model Alzheimer’s disease patients’ memory deficits and additionally present with various behavioural disturbances, such as aggressive behaviour. The present study investigated and confirmed significant sensitivity of the model to the aggression-lowering ability of the antipsychotic agent risperidone (CAS 106266-06-2). The sensitivity for such anti-aggressive action contributes to the therapeutic predictive validity of the APP23 model of Alzheimer’s disease, which can be used as a pre-clinical screening tool for the identification of novel anti-aggressive agents.

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