Synthesis and Antimicrobial Activity of Some Novel Thiazolidine-2,4-dione Derivatives

Arzu Menteşe; Meltem Ceylan-Ünlüsoy; Oya Bozdağ-Dündar; Nurten Altanlar; Rahmiye Ertan

doi:10.1055/s-0031-1296456

Arzneimittelforschung, Table of Contents

Arzneimittelforschung 2009; 59(12): 659-665
DOI: 10.1055/s-0031-1296456

Antibiotics · Antimycotics · Antiparasitics · Antiviral Drugs · Chemotherapeutics · Cytostatics

Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antimicrobial Activity of Some Novel Thiazolidine-2,4-dione Derivatives

Arzu Menteşe

¹Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)

,

Meltem Ceylan-Ünlüsoy

¹Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)

,

Oya Bozdağ-Dündar

¹Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)

,

Nurten Altanlar

²Ankara University, Faculty of Pharmacy, Department of Microbiology, Tandoğan, Ankara, (Turkey)

,

Rahmiye Ertan

¹Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)

› Author Affiliations

Abstract

In this study, a series of phenylefhylsul-fanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (VII a –f, VIII a–f) and 5-methyl-[1,2,4] triazolyl-sulfanyl-1,3-fhia-zolo-thiazolidine-2,4-dione derivatives (IXa–f, Xa–f) were synthesized and evaluated for their antibacterial and antifungal activities against S. aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), B. subtilis (ATCC 6633), E. coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used bacteria.

Key words

Antimicrobial activity - Thiazoles - Thiazolidine-2,4-diones - Triazoles

Full Text

References

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