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Arzneimittelforschung 2011; 61(1): 66-72
DOI: 10.1055/s-0031-1296169
DOI: 10.1055/s-0031-1296169
Special Themes
Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases
Further Information
Publication History
Publication Date:
28 November 2011 (online)
Abstract
Dihydroorotate dehydrogenase (DHODH), a novel and recently discovered enzyme, is involved in the biosynthesis of uridine. Leflunomide (CAS 75706-12-6), a drug approved for the treatment of treat rheumatoid arthritis (RA), was identified as an inhibitor of DHODH.
Structure based drug design using the leflunomide/DHODH X-ray structure yielded novel inhibitors with improved pharmacological properties. Such drug candidates are in clinical trials against various autoimmune diseases.
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