The Metabolic Role of Retinol Binding Protein 4: An Update

G. A. Christou; A. D. Tselepis; D. N. Kiortsis

doi:10.1055/s-0031-1295491

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2012; 44(01): 6-14
DOI: 10.1055/s-0031-1295491

Review

The Metabolic Role of Retinol Binding Protein 4: An Update

Authors

G. A. Christou

¹Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece
A. D. Tselepis

²Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece
D. N. Kiortsis

¹Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece

Abstract

Retinol binding protein 4 (RBP₄) is regarded as a novel cardiometabolic risk factor, which is secreted mainly by the hepatocytes and also by the adipose tissue. RBP₄ has been shown to induce insulin resistance, and plasma RBP₄ values are increased in type 2 diabetes mellitus, obesity, metabolic syndrome, and cardiovascular disease. Moreover, it has been found that circulating RBP₄ decreases during medical interventions that result in amelioration of the metabolic profile, such as diet, exercise, oral antidiabetic drugs, and hypolipidemic agents. However, only few of the RBP₄-related studies have investigated whether RBP₄ constitutes a causal factor of the above-mentioned metabolic conditions. Importantly, circulating RBP₄ is influenced by some nonmetabolic conditions, such as renal failure, acute illness, injury, and liver failure. Thus, further studies investigating the metabolic roles of RBP₄ should be carefully planned, taking into account the effects of nonmetabolic conditions on circulating RBP₄.

Key words

insulin resistance - lipid metabolism - adipose tissue - metabolic syndrome - adipokines - atherosclerosis

Full Text

References

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