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Neuropediatrics 2011; 42(06): 222-226
DOI: 10.1055/s-0031-1295480
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Total Antioxidant Capacity and Total Oxidant Status in Perinatal Asphyxia in Relation to Neurological Outcome

O. Aydemir
1   Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
,
M. Akar
1   Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
,
N. Uras
1   Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
,
Z. Eras
2   Department of Developmental Pediatrics, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
,
O. Erdeve
1   Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
,
S. S. Oguz
1   Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
,
U. Dilmen
1   Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
› Institutsangaben
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Publikationsverlauf

received 10. Juli 2011

accepted 31. Oktober 2011

Publikationsdatum:
05. Dezember 2011 (online)

    Lizenzen und Reprints

Abstract

This study aimed to investigate the global oxidant/antioxidant status of infants with perinatal asphyxia and its relation to neurological outcomes. A prospective controlled study including term infants with perinatal asphyxia was conducted. Blood samples were obtained from patients and controls at 6–24 h and on the 3rd day of life for TAC and TOS measurement and OSI values were calculated. Neurodevelopment was evaluated at 12 months of age in survivors using Bayley scales of infant development II (BSID II). 17 term infants with perinatal asphyxia and 17 healthy controls were enrolled. On the first day of life TAC, TOS and OSI were significantly higher in patients with perinatal asphyxia (p<0.001). Total antioxidant capacity decreased significantly on day 3 compared to first day of life in the patient group (p=0.04). Infants with seizures and abnormal amplitude-integrated electroencephalography recordings had higher TOS and OSI levels in the 1st day. There was no correlation between TAC, TOS and OSI levels and BSID II scores. In conclusion oxidant/antioxidant balance is disturbed in favour of oxidants in perinatal asphyxia. Degree of oxidative stress is related to severity of neurological involvement in the first days of life.

Key words

hypoxic-ischemic encephalopathy - newborn - neurological outcome - oxidative stress - seizures
 

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