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DOI: 10.1055/s-0031-1293200
First Trimester Miscarriage Evaluation
Publication History
Publication Date:
08 December 2011 (online)

ABSTRACT
Miscarriage is a relatively common occurrence for otherwise healthy women. Despite its frequency, evaluation for cause is rare. The most common cause of miscarriage is sporadic chromosome errors. Chromosomal analysis of the miscarriage offers an explanation in at least 50% of cases. Conventional cytogenetic evaluation can only be done on fresh tissue, so it is critical that the treating physician consider genetic testing at the time of the miscarriage. Ultrasound can estimate the gestational age at the time of miscarriage and identify major abnormalities in some embryos. A careful pathological examination can add to the evaluation by ruling out rare disorders with the highest recurrence risk. A multidisciplinary approach to miscarriage evaluation is essential to understanding the cause and risk of recurrence. A thorough evaluation of a miscarriage, in combination with emotional support, can often provide the necessary reassurance and confidence as the patient prepares for her next pregnancy.
KEYWORDS
Miscarriage - ultrasound - aneuploidy - pathology - pregnancy loss
REFERENCES
- 1
Goldstein S R.
Early detection of pathologic pregnancy by transvaginal sonography.
J Clin Ultrasound.
1990;
18
(4)
262-273
Reference Ris Wihthout Link
- 2
Sauerbrei E, Cooperberg P L, Poland B J.
Ultrasound demonstration of the normal fetal yolk sac.
J Clin Ultrasound.
1980;
8
(3)
217-220
Reference Ris Wihthout Link
- 3
Timor-Tritsch I E, Farine D, Rosen M G.
A close look at early embryonic development with the high-frequency transvaginal transducer.
Am J Obstet Gynecol.
1988;
159
(3)
676-681
Reference Ris Wihthout Link
- 4
Bradley W G, Fiske C E, Filly R A.
The double sac sign of early intrauterine pregnancy: use in exclusion of ectopic pregnancy.
Radiology.
1982;
143
(1)
223-226
Reference Ris Wihthout Link
- 5
Nyberg D A, Laing F C, Filly R A, Uri-Simmons M, Jeffrey Jr R B.
Ultrasonographic differentiation of the gestational sac of early intrauterine pregnancy
from the pseudogestational sac of ectopic pregnancy.
Radiology.
1983;
146
(3)
755-759
Reference Ris Wihthout Link
- 6
Stiller R J, Haynes de Regt R, Blair E.
Transvaginal ultrasonography in patients at risk for ectopic pregnancy.
Am J Obstet Gynecol.
1989;
161
(4)
930-933
Reference Ris Wihthout Link
- 7
Kadar N, Bohrer M, Kemmann E, Shelden R.
The discriminatory human chorionic gonadotropin zone for endovaginal sonography: a
prospective, randomized study.
Fertil Steril.
1994;
61
(6)
1016-1020
Reference Ris Wihthout Link
- 8
Romero R, Kadar N, Jeanty P et al..
Diagnosis of ectopic pregnancy: value of the discriminatory human chorionic gonadotropin
zone.
Obstet Gynecol.
1985;
66
(3)
357-360
Reference Ris Wihthout Link
- 9
Levi C S, Lyons E A, Lindsay D J.
Early diagnosis of nonviable pregnancy with endovaginal US.
Radiology.
1988;
167
(2)
383-385
Reference Ris Wihthout Link
- 10
Brown D L, Emerson D S, Felker R E, Cartier M S, Smith W C.
Diagnosis of early embryonic demise by endovaginal sonography.
J Ultrasound Med.
1990;
9
(11)
631-636
Reference Ris Wihthout Link
- 11
Rowling S E, Coleman B G, Langer J E, Arger P H, Nisenbaum H L, Horii S C.
First-trimester US parameters of failed pregnancy.
Radiology.
1997;
203
(1)
211-217
Reference Ris Wihthout Link
- 12
Achiron R, Tadmor O, Mashiach S.
Heart rate as a predictor of first-trimester spontaneous abortion after ultrasound-proven
viability.
Obstet Gynecol.
1991;
78
(3 Pt 1)
330-334
Reference Ris Wihthout Link
- 13
Laboda L A, Estroff J A, Benacerraf B R.
First trimester bradycardia. A sign of impending fetal loss.
J Ultrasound Med.
1989;
8
(10)
561-563
Reference Ris Wihthout Link
- 14
Howe R S, Isaacson K J, Albert J L, Coutifaris C B.
Embryonic heart rate in human pregnancy.
J Ultrasound Med.
1991;
10
(7)
367-371
Reference Ris Wihthout Link
- 15
Falco P, Milano V, Pilu G et al..
Sonography of pregnancies with first-trimester bleeding and a viable embryo: a study
of prognostic indicators by logistic regression analysis.
Ultrasound Obstet Gynecol.
1996;
7
(3)
165-169
Reference Ris Wihthout Link
- 16
Doubilet P M, Benson C B.
Outcome of first-trimester pregnancies with slow embryonic heart rate at 6-7 weeks
gestation and normal heart rate by 8 weeks at US.
Radiology.
2005;
236
(2)
643-646
Reference Ris Wihthout Link
- 17
Bromley B, Harlow B L, Laboda L A, Benacerraf B R.
Small sac size in the first trimester: a predictor of poor fetal outcome.
Radiology.
1991;
178
(2)
375-377
Reference Ris Wihthout Link
- 18
Pedersen J F, Mantoni M.
Prevalence and significance of subchorionic hemorrhage in threatened abortion: a sonographic
study.
AJR Am J Roentgenol.
1990;
154
(3)
535-537
Reference Ris Wihthout Link
- 19
Bennett G L, Bromley B, Lieberman E, Benacerraf B R.
Subchorionic hemorrhage in first-trimester pregnancies: prediction of pregnancy outcome
with sonography.
Radiology.
1996;
200
(3)
803-806
Reference Ris Wihthout Link
- 20
Odeh M, Tendler R, Kais M, Grinin V, Ophir E, Bornstein J.
Gestational sac volume in missed abortion and anembryonic pregnancy compared to normal
pregnancy.
J Clin Ultrasound.
2010;
38
(7)
367-371
Reference Ris Wihthout Link
- 21
Ball E, Robson S C, Ayis S, Lyall F, Bulmer J N.
Early embryonic demise: no evidence of abnormal spiral artery transformation or trophoblast
invasion.
J Pathol.
2006;
208
(4)
528-534
Reference Ris Wihthout Link
- 22
Novak R W, Malone J M, Robinson H B.
The role of the pathologist in the evaluation of first trimester abortions.
Pathol Annu.
1990;
25
(Pt 1)
297-311
Reference Ris Wihthout Link
- 23
Jindal P, Regan L, Fourkala E O et al..
Placental pathology of recurrent spontaneous abortion: the role of histopathological
examination of products of conception in routine clinical practice: a mini review.
Hum Reprod.
2007;
22
(2)
313-316
Reference Ris Wihthout Link
- 24
Boyd T K, Redline R W.
Chronic histiocytic intervillositis: a placental lesion associated with recurrent
reproductive loss.
Hum Pathol.
2000;
31
(11)
1389-1396
Reference Ris Wihthout Link
- 25
Marchaudon V, Devisme L, Petit S, Ansart-Franquet H, Vaast P, Subtil D.
Chronic histiocytic intervillositis of unknown etiology: clinical features in a consecutive
series of 69 cases.
Placenta.
2011;
32
(2)
140-145
Reference Ris Wihthout Link
- 26
Boyd T K, Redline R W.
Chronic histiocytic intervillositis: a placental lesion associated with recurrent
reproductive loss.
Hum Pathol.
2000;
31
(11)
1389-1396
Reference Ris Wihthout Link
- 27
Katzman P J, Genest D R.
Maternal floor infarction and massive perivillous fibrin deposition: histological
definitions, association with intrauterine fetal growth restriction, and risk of recurrence.
Pediatr Dev Pathol.
2002;
5
(2)
159-164
Reference Ris Wihthout Link
- 28
Sebire N J, Backos M, El Gaddal S, Goldin R D, Regan L.
Placental pathology, antiphospholipid antibodies, and pregnancy outcome in recurrent
miscarriage patients.
Obstet Gynecol.
2003;
101
(2)
258-263
Reference Ris Wihthout Link
- 29
Redline R W, Zaragoza M, Hassold T.
Prevalence of developmental and inflammatory lesions in nonmolar first-trimester spontaneous
abortions.
Hum Pathol.
1999;
30
(1)
93-100
Reference Ris Wihthout Link
- 30
Rushton D I.
Simplified classification of spontaneous abortions.
J Med Genet.
1978;
15
(1)
1-9
Reference Ris Wihthout Link
- 31
Waters B L, Ashikaga T.
Significance of perivillous fibrin/oid deposition in uterine evacuation specimens.
Am J Surg Pathol.
2006;
30
(6)
760-765
Reference Ris Wihthout Link
- 32
Oyer C E, Cai R, Coughlin J J, Singer D B.
First trimester pregnancy loss associated with varicella zoster virus infection: histological
definition of a case.
Hum Pathol.
1998;
29
(1)
94-95
Reference Ris Wihthout Link
- 33
Redline R W, Abramowsky C R.
Clinical and pathologic aspects of recurrent placental villitis.
Hum Pathol.
1985;
16
(7)
727-731
Reference Ris Wihthout Link
- 34
Russell P, Atkinson K, Krishnan L.
Recurrent reproductive failure due to severe placental villitis of unknown etiology.
J Reprod Med.
1980;
24
(2)
93-98
Reference Ris Wihthout Link
- 35
Edmondson N, Bocking A, Machin G, Rizek R, Watson C, Keating S.
The prevalence of chronic deciduitis in cases of preterm labor without clinical chorioamnionitis.
Pediatr Dev Pathol.
2009;
12
(1)
16-21
Reference Ris Wihthout Link
- 36
Novak R, Agamanolis D, Dasu S et al..
Histologic analysis of placental tissue in first trimester abortions.
Pediatr Pathol.
1988;
8
(5)
477-482
Reference Ris Wihthout Link
- 37
Bayraktar M R, Ozerol I H, Gucluer N, Celik O.
Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women.
Int J Infect Dis.
2010;
14
(2)
e90-e95
Reference Ris Wihthout Link
- 38
Check J H.
A practical approach to the prevention of miscarriage: Part 3—Passive immunotherapy.
Clin Exp Obstet Gynecol.
2010;
37
(2)
81-83
Reference Ris Wihthout Link
- 39
Ville Y, Khalil A, Homphray T, Moscoso G.
Diagnostic embryoscopy and fetoscopy in the first trimester of pregnancy.
Prenat Diagn.
1997;
17
(13)
1237-1246
Reference Ris Wihthout Link
- 40
Philipp T, Kalousek D K.
Generalized abnormal embryonic development in missed abortion: embryoscopic and cytogenetic
findings.
Am J Med Genet.
2002;
111
(1)
43-47
Reference Ris Wihthout Link
- 41
Philipp T, Feichtinger W, Van Allen M I, Separovic E, Reiner A, Kalousek D K.
Abnormal embryonic development diagnosed embryoscopically in early intrauterine deaths
after in vitro fertilization: a preliminary report of 23 cases.
Fertil Steril.
2004;
82
(5)
1337-1342
Reference Ris Wihthout Link
- 42
Philipp T, Philipp K, Reiner A, Beer F, Kalousek D K.
Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in
the pathogenesis of developmental defects of early failed pregnancies.
Hum Reprod.
2003;
18
(8)
1724-1732
Reference Ris Wihthout Link
- 43
Philipp T, Kalousek D K.
Morphology of the 45,X embryo: an embryoscopic study.
Am J Med Genet A.
2003;
120A
(3)
314-319
Reference Ris Wihthout Link
- 44
Philipp T, Grillenberger K, Separovic E R, Philipp K, Kalousek D K.
Effects of triploidy on early human development.
Prenat Diagn.
2004;
24
(4)
276-281
Reference Ris Wihthout Link
- 45
Pauli R M.
Stillbirth: fetal disorders.
Clin Obstet Gynecol.
2010;
53
(3)
646-655
Reference Ris Wihthout Link
- 46
Hogge W A, Byrnes A L, Lanasa M C, Surti U.
The clinical use of karyotyping spontaneous abortions.
Am J Obstet Gynecol.
2003;
189
(2)
397-400, discussion 400–402
Reference Ris Wihthout Link
- 47
Simpson J L.
Causes of fetal wastage.
Clin Obstet Gynecol.
2007;
50
(1)
10-30
Reference Ris Wihthout Link
- 48
Bell K A, Van Deerlin P G, Haddad B R, Feinberg R F.
Cytogenetic diagnosis of “normal 46,XX” karyotypes in spontaneous abortions frequently
may be misleading.
Fertil Steril.
1999;
71
(2)
334-341
Reference Ris Wihthout Link
- 49
Lomax B, Tang S, Separovic E et al..
Comparative genomic hybridization in combination with flow cytometry improves results
of cytogenetic analysis of spontaneous abortions.
Am J Hum Genet.
2000;
66
(5)
1516-1521
Reference Ris Wihthout Link
- 50
Peng H H, Chao A S, Wang T H, Chang Y L, Chang S D.
Prenatally diagnosed balanced chromosome rearrangements: eight years' experience.
J Reprod Med.
2006;
51
(9)
699-703
Reference Ris Wihthout Link
- 51 Gardner R JM, Sutherland G R eds.. Chromosome Abnormalities and Genetic Counseling. 3rd ed. New York, NY: Oxford University Press; 2004
Reference Ris Wihthout Link
- 52
Sugiura-Ogasawara M, Aoki K, Fujii T et al..
Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or
maternal carrier of a structural chromosome rearrangement.
J Hum Genet.
2008;
53
(7)
622-628
Reference Ris Wihthout Link
- 53
Franssen M T, Korevaar J C, Leschot N J et al..
Selective chromosome analysis in couples with two or more miscarriages: case-control
study.
BMJ.
2005;
331
(7509)
137-141
Reference Ris Wihthout Link
- 54
Tharapel A T, Tharapel S A, Bannerman R M.
Recurrent pregnancy losses and parental chromosome abnormalities: a review.
Br J Obstet Gynaecol.
1985;
92
(9)
899-914
Reference Ris Wihthout Link
- 55
Stephenson M D, Sierra S.
Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier
of a structural chromosome rearrangement.
Hum Reprod.
2006;
21
(4)
1076-1082
Reference Ris Wihthout Link
- 56
Klock S C, Chang G, Hiley A, Hill J.
Psychological distress among women with recurrent spontaneous abortion.
Psychosomatics.
1997;
38
(5)
503-507
Reference Ris Wihthout Link
Ruth B. LathiM.D.
Department of Obstetrics and Gynecology, Recurrent Pregnancy Loss Program, Stanford
University
300 Pasteur Drive HH333, Stanford, CA 94305
Email: rlathi@stanford.edu