Exercise Dose Response in Muscle

B. D. Duscha; B. H. Annex; J. L. Johnson; K. Huffman; J. Houmard; W. E. Kraus

doi:10.1055/s-0031-1291323

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2012; 33(03): 218-223
DOI: 10.1055/s-0031-1291323

Training & Testing

Exercise Dose Response in Muscle

B. D. Duscha

¹Division of Cardiovascular Medicine, Medicical Center, Duke University, Durham, North Carolina, United States

,

B. H. Annex

²Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, United States

,

J. L. Johnson

¹Division of Cardiovascular Medicine, Medicical Center, Duke University, Durham, North Carolina, United States

,

K. Huffman

³Division of Rheumatology, Medical Center, Duke University, Durham, North Carolina, United States

,

J. Houmard

⁴Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina, United States

,

W. E. Kraus

¹Division of Cardiovascular Medicine, Medicical Center, Duke University, Durham, North Carolina, United States

› Institutsangaben

Abstract

Exercise increases peak VO₂ partially through muscle adaptations. However, understanding muscle adaptations related to exercise dose is incomplete. This study investigated exercise training dose on capillaries per fiber and capillaries per area; and citrate synthase from vastus lateralis and related both to changes in peak VO₂. This randomized trial compared 3 exercise doses: low amount-moderate intensity (n=40)_, low amount-high intensity (n=47), high amount-high intensity (n=41), and a control group (n=35). Both measures of capillary supply increased in all exercise groups (p<0.05). Low amount-high intensity and high amount-high intensity improved citrate synthase (p<0.05) and the low amount-moderate intensity citrate synthase approached significance (p=0.059). Muscle improvements were only related to improvements in peak VO₂ in high amount-high intensity (citrate synthase, r=0.304; capillaries:fiber, r= − 0.318; p<0.05 and capillaries/mm² r= − 0.310, p<0.05). These data suggest muscle adaptations occur following both low and high exercise doses, but are only related to improved peak VO₂ following high amount-high intensity training.

Key words

exercise training - capillary density - muscle adaptations - citrate synthase

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