Dehydrogenative Synthesis of C3-Azolylindoles via Copper-Promoted Annulative Direct Coupling of o-Alkynylanilines

Abstract

A copper-promoted annulative direct coupling of o-alkynylaniline derivatives with 1,3,4-oxadiazoles for the synthesis of C3-azolylindoles has been developed. The copper-based system provides a new protocol for the dehydrogenative construction of indole­–oxadiazole conjugations from nonhalogenated and nonmetalated starting materials.

Key words

copper - dehydrogenative coupling - indoles - C–H functionalization - oxadiazoles

• References

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See also:
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