Synthesis of 3-Substituted Isocoumarin Derivatives via CuI-Catalyzed Reaction of o-Bromobenzamides with 1,3-Diketones

Shangjun Cai; Fei Wang; Chanjuan Xi

doi:10.1055/s-0031-1290949

Synthesis, Table of Contents

Synthesis 2012; 44(12): 1892-1897
DOI: 10.1055/s-0031-1290949

paper

Synthesis of 3-Substituted Isocoumarin Derivatives via CuI-Catalyzed Reaction of o-Bromobenzamides with 1,3-Diketones

Authors

Shangjun Cai

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China, Email: cjxi@tsinghua.edu.cn
Fei Wang

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China, Email: cjxi@tsinghua.edu.cn
Chanjuan Xi*

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China, Email: cjxi@tsinghua.edu.cn

Abstract

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Abstract

An approach to a variety of 3-substituted isocoumarins has been developed. The reaction proceeded from o-bromobenzamide derivatives and 1,3-diketones via CuI-catalyzed reaction in DMF under the action of K₃PO₄ at 120 °C without ligands or additives.

Key words

copper - domino reaction - isocoumarins - o-bromobenzamides - 1,3-diketones

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