One-Pot Synthesis of Fused
Pyridazino[4,5-b][1,4]oxazepine-diones
via Smiles Rearrangement

Yanli Liu; Ying Ma; Chunjing Zhan; Aiping Huang; Chen Ma

doi:10.1055/s-0031-1290073

LETTER

One-Pot Synthesis of Fused Pyridazino[4,5-b][1,4]oxazepine-diones via Smiles Rearrangement

Yanli Liu^a, Ying Ma^a, Chunjing Zhan^a, Aiping Huang^a, Chen Ma*^a,b
^a School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China
Fax: +86(531)88564464; e-Mail: chenma@sdu.edu.cn;
^b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, P. R. of China

Abstract

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Abstract

Fused pyridazino[4,5-b][1,4]oxazepine-diones were easily obtained in moderate to excellent yields via Smiles rearrangement. The synthetic approach is supported by a one-pot coupling-Smiles rearrangement-cyclization process. This process has potential applications in the synthesis of biologically and medicinally relevant compounds.

Key words

pyridazino[4,5-b][1,4]oxazepine-dione - one-pot - synthesis - Smiles rearrangement - tandem reaction

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References

References and Notes

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