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Synthesis 2012(3): 423-430  
DOI: 10.1055/s-0031-1289659
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Ester Synthesis from Allyl and Benzyl Halides and Alcohols by Palladium-Catalyzed Carbonylation

Sara Tommasi, Serena Perrone, Francesca Rosato, Antonio Salomone, Luiginio Troisi*
Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, via Prov. le Lecce-Monteroni, 73100 Lecce, Italy
Fax: +39(0832)298732; e-Mail: luigino.troisi@unisalento.it;
Further Information

Publication History

Received 13 October 2011
Publication Date:
29 December 2011 (online)

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Abstract

A mild and efficient one-pot synthesis of esters based on the Pd-catalyzed alkoxy- and aryloxycarbonylation of allylic and benzylic halides is described. The methodology has been applied to primary, secondary, and tertiary alcohols as well as to phenol derivatives. The O-protection of some biologically relevant molecules is also reported.

Key words

alcohols - allyl halides - benzyl halides - esterification - Pd-catalysis

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