Ti-Mediated Tandem Ethylation and Functionalization of Allylic
Alcohols

P. P. Das; I. L. Lysenko; J. K. Cha

doi:10.1055/s-0031-1289344

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2011(12): 1353-1353
DOI: 10.1055/s-0031-1289344

Metal-Mediated Synthesis

Ti-Mediated Tandem Ethylation and Functionalization of Allylic Alcohols

Contributor(s): Paul Knochel, Andreas K. Steib
P. P. Das, I. L. Lysenko, J. K. Cha*
Wayne State University, Detroit, USA

Further Information

Publication History

Publication Date:
18 November 2011 (online)

Permissions and Reprints

Significance

A new stereoselective alkylation of allylic alcohols by trapping of the presumed organometallic intermediates with suitable electrophiles has been disclosed. This titanium-mediated reaction proceeds in an S_N2′ manner and uses EtMgBr as alkylation reagent and ClTi(Oi-Pr)₃ as scavenger for magnesium alkoxides.