Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2011(11): 1247-1247
DOI: 10.1055/s-0031-1289263
DOI: 10.1055/s-0031-1289263
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Catalytic Enantioselective Desymmetrization of meso-Diamines
C. K. De, D. Seidel*
Rutgers, The State University of Ney Jersey, Piscataway, USA
Further Information
Publication History
Publication Date:
19 October 2011 (online)
Significance
Seidel and De report the first catalytic enantioselective desymmetrization of meso-1,2-diaryl-1,2-diaminethanes by monobenzoylation catalyzed by a combination of DMAP and a chiral amido-thiourea. The reaction scope shows that substrates with electron-withdrawing and -donating groups at different positions on the aromatic ring led to the desymmetrization products in moderate to good yield and with good enantioselectivity. The products of diacylation have not been observed. The authors add value to their work with the synthesis of urea and thiourea compounds with good enantioselectivities.