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Synfacts 2011(11): 1149-1149  
DOI: 10.1055/s-0031-1289258
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Rho-Kinase Inhibitor Y-27632

Contributor(s): Philip Kocienski
J. Paleček, R. Zweigerdt, R. Olmer, U. Martin, A. Kirschning*, G. Dräger*
Leibniz University Hannover and Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover, Germany
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

Y-27632 is a selective ROCK (Rho-associated coiled-coil-forming protein serine/threonine kinase) inhibitor which has played a major role in stem cell research and in understanding a wide range of disease states associated with Rho-kinase. It was first synthesized by workers at Yoshitomi Pharmaceuticals (US Patent 4997834, 1991; US Patent 5478838, 1995).