Skull Base Rep 2011; 1(2): 145-150
DOI: 10.1055/s-0031-1287687
© Thieme Medical Publishers

Benign Inverted Papilloma with Intracranial Extension: Prognostic Factors and Outcomes

Ernest J. Wright1 , Natalya Chernichenko2 , Eylem Ocal1 , Jennifer Moliterno1 , Ketan R. Bulsara1 , Benjamin L. Judson2 , 3
  • 1Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
  • 2Department of Otolaryngology, Yale University School of Medicine, New Haven, Connecticut
  • 3Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
Further Information

Publication History

Publication Date:
29 September 2011 (online)

ABSTRACT

We describe a case of benign inverted papilloma with intracranial extension treated with endoscopic resection combined with craniotomy. Intracranial involvement of inverted papilloma, in the absence of malignancy, is uncommon. We present an analysis of the literature identifying the characteristics and outcomes of benign intracranial inverted papilloma. PubMed database was searched using keywords intracranial, inverted or inverting, and papilloma. There are 17 reports of benign inverted papilloma with intracranial extension reported with a mean age of 49.2 years (range, 23 to 92 years), a female predominance, 22% of cases with an associated mucocele, and 60% recurrent disease. The most common sites of invasion are the frontal sinus or cribriform plate. The prognosis for benign intracranial inverted papilloma is dependent on the presence of dural invasion and the achievement of total resection. There are no reported recurrences after craniofacial resection with a mean follow-up of 7.9 years. Adjuvant radiation therapy has demonstrated benefit in cases of residual disease after resection. We expect that endoscopic resection, the standard treatment for sinonasal inverted papilloma, will be increasingly used in the presence of intracranial extension.

REFERENCES

  • 1 Ringertz N. Pathology of malignant tumors arising in nasal and paranasal cavities and maxilla.  Acta Otolaryngol Suppl Stockh. 1938;  27 31-42
  • 2 Snow J BJR, Wackym P A. Ballenger's Otorhinolaryngology Head and Neck Surgery. 17 ed. Shelton: Pmph USA; 2009
  • 3 Dolgin S R, Zaveri V D, Casiano R R, Maniglia A J. Different options for treatment of inverting papilloma of the nose and paranasal sinuses: a report of 41 cases.  Laryngoscope. 1992;  102 (3) 231-236
  • 4 Myers E N, Schramm Jr V L, Barnes Jr E L. Management of inverted papilloma of the nose and paranasal sinuses.  Laryngoscope. 1981;  91 (12) 2071-2084
  • 5 Myers E N, Fernau J L, Johnson J T, Tabet J C, Barnes E L. Management of inverted papilloma.  Laryngoscope. 1990;  100 (5) 481-490
  • 6 Vrabec D P. The inverted Schneiderian papilloma: a 25-year study.  Laryngoscope. 1994;  104 (5 Pt 1) 582-605
  • 7 Weissler M C, Montgomery W W, Turner P A, Montgomery S K, Joseph M P. Inverted papilloma.  Ann Otol Rhinol Laryngol. 1986;  95 (3 Pt 1) 215-221
  • 8 Lawson W, Ho B T, Shaari C M, Biller H F. Inverted papilloma: a report of 112 cases.  Laryngoscope. 1995;  105 (3 Pt 1) 282-288
  • 9 Visvanathan V, Wallace H, Chumas P, Makura Z G. An unusual presentation of inverted papilloma: case report and literature review.  J Laryngol Otol. 2010;  124 (1) 101-104
  • 10 Vural E, Suen J Y, Hanna E. Intracranial extension of inverted papilloma: An unusual and potentially fatal complication.  Head Neck. 1999;  21 (8) 703-706
  • 11 Mendenhall W M, Million R R, Cassisi N J, Pierson K K. Biologically aggressive papillomas of the nasal cavity: the role of radiation therapy.  Laryngoscope. 1985;  95 (3) 344-347
  • 12 Guedea F, Mendenhall W M, Parsons J T, Million R R. The role of radiation therapy in inverted papilloma of the nasal cavity and paranasal sinuses.  Int J Radiat Oncol Biol Phys. 1991;  20 (4) 777-780
  • 13 Miller P J, Jacobs J, Roland Jr J T, Cooper J, Mizrachi H H. Intracranial inverting papilloma.  Head Neck. 1996;  18 (5) 450-453 discussion 454
  • 14 Lewis W J, Richter H A, Jabourian Z. Craniofacial resection for large tumors of the paranasal sinuses.  Ear Nose Throat J. 1989;  68 (7) 539-547
  • 15 Lyons B M, Donald P J, Sykes J M, Boggan J E. Craniofacial resection for intracranial inverting papilloma and frontal sinus mucocele.  Skull Base Surg. 1992;  2 (2) 92-97
  • 16 Peterson I M, Heim C. Inverted squamous papilloma with neuro-ophthalmic features.  J Clin Neuroophthalmol. 1991;  11 (1) 35-38
  • 17 van Olphen A F, Lubsen H, van 't Verlaat J W. An inverted papilloma with intracranial extension.  J Laryngol Otol. 1988;  102 (6) 534-537
  • 18 Momose K J, Weber A L, Goodman M, MacMillan Jr A S, Roberson G H. Radiological aspects of inverted papilloma.  Radiology. 1980;  134 (1) 73-79
  • 19 Phillips P P, Gustafson R O, Facer G W. The clinical behavior of inverting papilloma of the nose and paranasal sinuses: report of 112 cases and review of the literature.  Laryngoscope. 1990;  100 (5) 463-469
  • 20 Kristensen S, Vorre P, Elbrønd O, Søgaard H. Nasal Schneiderian papillomas: a study of 83 cases.  Clin Otolaryngol Allied Sci. 1985;  10 (3) 125-134
  • 21 Hyams V J. Papillomas of the nasal cavity and paranasal sinuses. A clinicopathological study of 315 cases.  Ann Otol Rhinol Laryngol. 1971;  80 (2) 192-206
  • 22 Hug E B, Wang C C, Montgomery W W, Goodman M L. Management of inverted papilloma of the nasal cavity and paranasal sinuses: importance of radiation therapy.  Int J Radiat Oncol Biol Phys. 1993;  26 (1) 67-72

Benjamin L JudsonM.D. 

Assistant Professor, Section of Otolaryngology, Department of Surgery

800 Howard Avenue, New Haven, CT 06519-1369

Email: benjamin.judson@yale.edu