Skull Base Rep 2011; 1(2): 145-150
DOI: 10.1055/s-0031-1287687
© Thieme Medical Publishers

Benign Inverted Papilloma with Intracranial Extension: Prognostic Factors and Outcomes

Ernest J. Wright1 , Natalya Chernichenko2 , Eylem Ocal1 , Jennifer Moliterno1 , Ketan R. Bulsara1 , Benjamin L. Judson2 , 3
  • 1Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
  • 2Department of Otolaryngology, Yale University School of Medicine, New Haven, Connecticut
  • 3Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
Further Information

Publication History

Publication Date:
29 September 2011 (online)


We describe a case of benign inverted papilloma with intracranial extension treated with endoscopic resection combined with craniotomy. Intracranial involvement of inverted papilloma, in the absence of malignancy, is uncommon. We present an analysis of the literature identifying the characteristics and outcomes of benign intracranial inverted papilloma. PubMed database was searched using keywords intracranial, inverted or inverting, and papilloma. There are 17 reports of benign inverted papilloma with intracranial extension reported with a mean age of 49.2 years (range, 23 to 92 years), a female predominance, 22% of cases with an associated mucocele, and 60% recurrent disease. The most common sites of invasion are the frontal sinus or cribriform plate. The prognosis for benign intracranial inverted papilloma is dependent on the presence of dural invasion and the achievement of total resection. There are no reported recurrences after craniofacial resection with a mean follow-up of 7.9 years. Adjuvant radiation therapy has demonstrated benefit in cases of residual disease after resection. We expect that endoscopic resection, the standard treatment for sinonasal inverted papilloma, will be increasingly used in the presence of intracranial extension.


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Benjamin L JudsonM.D. 

Assistant Professor, Section of Otolaryngology, Department of Surgery

800 Howard Avenue, New Haven, CT 06519-1369