Skull Base 2011; 21(6): 365-372
DOI: 10.1055/s-0031-1287677

© Thieme Medical Publishers

Comparison Between Manual and Semiautomated Volumetric Measurements of Pituitary Adenomas

Qasim Al Hinai1 , Kelvin Mok1 , Anthony Zeitouni2 , Bruno Gagnon3 , Abdul Razag Ajlan1 , Juan Rivera4 , Marc Tewfik2 , Denis Sirhan1
  • 1Division of Neurosurgery, McGill University, Montreal, Canada
  • 2Division of Otolaryngology and Head and Neck, McGill University, Montreal, Canada
  • 3Division of Medicine and Oncology, McGill University, Montreal, Canada
  • 4Division of Endocrinology, McGill University, Montreal, Canada
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16. September 2011 (online)


Linear measurements have many limitations. The aim of this study is to compare manual and semiautomated volumetric measurements of pituitary adenomas. Magnetic resonance imaging (MRI) scans of 38 patients with pituitary adenomas were analyzed. Preoperative MRI was acquired on a 1.5 T. MRI volumes of the pituitary adenomas were obtained by two methods: manual (MA) and semiautomated (SA). The concurrent validity for SA and MA methods on 38 patients in the form of correlation coefficient was 0.97 (p < 0.0001). The intraobserver and the interobserver correlation coefficients for SA volumes were both 0.98, as for the intraobserver MA volumes were 0.98. Although the results of both methods are comparable, analysis of volumetric measurements by SA method is more time-efficient than MA segmentation. Precision in volumetric measurement techniques is likely to increase reliability of posttherapeutic monitoring of pituitary adenomas.


Denis Sirhan M.D. 

Department of Neurosurgery, Montreal Neurological Hospital/Institute, McGill University

109-3801 University Avenue, Montreal, QC H3A 2B4, Canada