Skull Base 2011; 21(6): 365-372
DOI: 10.1055/s-0031-1287677

© Thieme Medical Publishers

Comparison Between Manual and Semiautomated Volumetric Measurements of Pituitary Adenomas

Qasim Al Hinai1 , Kelvin Mok1 , Anthony Zeitouni2 , Bruno Gagnon3 , Abdul Razag Ajlan1 , Juan Rivera4 , Marc Tewfik2 , Denis Sirhan1
  • 1Division of Neurosurgery, McGill University, Montreal, Canada
  • 2Division of Otolaryngology and Head and Neck, McGill University, Montreal, Canada
  • 3Division of Medicine and Oncology, McGill University, Montreal, Canada
  • 4Division of Endocrinology, McGill University, Montreal, Canada
Further Information

Publication History

Publication Date:
16 September 2011 (online)


Linear measurements have many limitations. The aim of this study is to compare manual and semiautomated volumetric measurements of pituitary adenomas. Magnetic resonance imaging (MRI) scans of 38 patients with pituitary adenomas were analyzed. Preoperative MRI was acquired on a 1.5 T. MRI volumes of the pituitary adenomas were obtained by two methods: manual (MA) and semiautomated (SA). The concurrent validity for SA and MA methods on 38 patients in the form of correlation coefficient was 0.97 (p < 0.0001). The intraobserver and the interobserver correlation coefficients for SA volumes were both 0.98, as for the intraobserver MA volumes were 0.98. Although the results of both methods are comparable, analysis of volumetric measurements by SA method is more time-efficient than MA segmentation. Precision in volumetric measurement techniques is likely to increase reliability of posttherapeutic monitoring of pituitary adenomas.


  • 1 Yushkevich P A, Piven J, Hazlett H C et al. User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability.  Neuroimage. 2006;  31 (3) 1116-1128
  • 2 Takano K, Utsunomiya H, Ono H, Ohfu M, Okazaki M. Normal development of the pituitary gland: assessment with three-dimensional MR volumetry.  AJNR Am J Neuroradiol. 1999;  20 (2) 312-315
  • 3 Marziali S, Gaudiello F, Bozzao A et al. Evaluation of anterior pituitary gland volume in childhood using three-dimensional MRI.  Pediatr Radiol. 2004;  34 (7) 547-551
  • 4 Fink A M, Vidmar S, Kumbla S et al. Age-related pituitary volumes in prepubertal children with normal endocrine function: volumetric magnetic resonance data.  J Clin Endocrinol Metab. 2005;  90 (6) 3274-3278
  • 5 Ertekin T, Acer N, Turgut A T, Aycan K, Ozçelik O, Turgut M. Comparison of three methods for the estimation of the pituitary gland volume using magnetic resonance imaging: a stereological study.  Pituitary. 2011;  14 (1) 31-38
  • 6 Pamir M N, Kiliç T, Belirgen M, Abacioğlu U, Karabekiroğlu N. Pituitary adenomas treated with gamma knife radiosurgery: volumetric analysis of 100 cases with minimum 3 year follow-up.  Neurosurgery. 2007;  61 (2) 270-280 discussion 280
  • 7 Wowra B, Stummer W. Efficacy of gamma knife radiosurgery for nonfunctioning pituitary adenomas: a quantitative follow up with magnetic resonance imaging-based volumetric analysis.  J Neurosurg. 2002;  97 (5, Suppl) 429-432
  • 8 Buhk J H, Jung S, Psychogios M N et al. Tumor volume of growth hormone-secreting pituitary adenomas during treatment with pegvisomant: a prospective multicenter study.  J Clin Endocrinol Metab. 2010;  95 (2) 552-558
  • 9 Benesch H, Felber S R, Finkenstedt G, Kremser C, Stockhammer G, Aichner F T. MR volumetry for monitoring intramuscular bromocriptine treatment in macroprolactinomas.  J Comput Assist Tomogr. 1995;  19 (6) 866-870
  • 10 McLachlan M S, Williams E D, Fortt R W, Doyle F H. Estimation of pituitary gland dimensions from radiographs of the sella turcica. A post-mortem study.  Br J Radiol. 1968;  41 (485) 323-330

Denis Sirhan M.D. 

Department of Neurosurgery, Montreal Neurological Hospital/Institute, McGill University

109-3801 University Avenue, Montreal, QC H3A 2B4, Canada