Geburtshilfe Frauenheilkd 2011; 71 - O_19
DOI: 10.1055/s-0031-1286474

Perineuralscheideninfiltration beim Zervixkarzinom – prognostische Bedeutung

A Meinel 1, U Fischer 1, 2, K Bilek 2, B Hentschel 3, LC Horn 1
  • 1Institute of Pathology, Division of Breast, Gynecologic & Perinatal Pathology, University of Leipzig
  • 2Department of Obstetrics and Gynecology (Institute of Trier), University of Leipzig
  • 3Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig

Fragestellung:

Limited information exists about the occurency and the impact of perineural invasion (PNI) in patients with cervical carcinoma (CX).

Methode:

The original histologic slides from patients primarily treated by radical hysterectomy and systematic pelvic lymphadenectomy were re-examined regarding the occurrence of PNI. PNI was correlated to recurrence free (RFS) and overall survival (OS).

Ergebnisse:

35.1% of all patients (68/194) represented perineural invasion (=PNI). The 5-year-overall-survival-rate was significantly decreased in patients representing PNI, when they were compared with those without PNI (51.1% [95% CI: 38.0 to 64.2] versus 75.6% [95% CI: 67.8 to 83.4]; p=0.001). In a separate analysis the prognostic impact persisted in the node negative, but disappeared in the node positive cases. In multivariate analysis, pelvic lymph node involvement and PNI were independent prognostic factors for overall survival.

Schlussfolgerung:

Perineural invasion (PNI) is seen in about one third of patients with cervical carcinoma. Patients affected by PNI represented a decreased overall survival. Further studies are required to get a deeper insight in the clinical impact and the pathogenetic mechanisms of PNI in CX.