Exp Clin Endocrinol Diabetes 2011; 119(10): 628-632
DOI: 10.1055/s-0031-1286295
Article
© J. A. Barth Verlag in George Thieme Verlag KG Stuttgart · New York

The Promoter Variant -803 G>A in the RBP4 gene is not Associated with BMI, Metabolic Parameters or Blood Pressure in Caucasian Children

D. Friebe
1   University Hospital for Children & Adolescents, University of Leipzig, Germany
,
P. Kovacs
2   Interdisciplinary Centre of Clinical Research, University of Leipzig, Germany
,
M. Neef
1   University Hospital for Children & Adolescents, University of Leipzig, Germany
,
S. Blüher
1   University Hospital for Children & Adolescents, University of Leipzig, Germany
3   Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
,
D. Schleinitz
2   Interdisciplinary Centre of Clinical Research, University of Leipzig, Germany
,
W. Kiess
1   University Hospital for Children & Adolescents, University of Leipzig, Germany
,
A. Körner
1   University Hospital for Children & Adolescents, University of Leipzig, Germany
3   Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
› Author Affiliations
Further Information

Publication History

received 24 January 2011
first decision 11 August 2011

accepted 17 August 2011

Publication Date:
08 November 2011 (online)

Abstract

Objective:

Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes.

Methods:

We genotyped this polymorphism in a cohort of 304 lean and 283 obese children to assess a potential association with early onset obesity and blood pressure and evaluated the effect of this SNP on metabolic parameters in a smaller subset.

Results:

The allele frequency of -803 G>A was similar in obese compared to lean subjects (0.159 vs. 0.191, P=0.318). We did not detect an association of the variant with adiposity parameters nor with parameters of glucose and lipid metabolism or blood pressure in quantitative analyses.

Conclusion:

Our study revealed that the promoter polymorphism -803 G>A in RBP4 is not associated with BMI, metabolic parameters or blood pressure in Caucasian children.

 
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