Acute Lymphoblastic Leukemia in a 10-Year-Old Boy With Cystic Fibrosis – Improvement of Pulmonary Function During Chemotherapy in spite of Intermittent Pseudomonas Aeruginosa Colonisation

Background

Multiorgan involvement in cystic fibrosis (CF), including chronic airway infection with pathogens like Pseudomonas aeruginosa, is a critical risk factor in patients with malignancy during aggressive immunosuppressive therapy, and was therefore formerly associated with high mortality rates. A 10 year old boy with CF and acute lymphoblastic leukemia (ALL) underwent induction and reinduction treatment without severe infectious complications whereas lung function improved.

Key words

cystic fibrosis - leukemia - pulmonary function - osteopenia - cerebral venous thrombosis - liver toxicity

Schlüsselwörter

zystische Fibrose - Leukämie - Lungenfunktion - Osteopenie - Sinusvenenthrombose - Lebertoxizität

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