Planta Med 2011; 77 - PM218
DOI: 10.1055/s-0031-1282976

Cardioprotective effect of Algerian medicinal plant Globularia alypum extract against cardiotoxicity of Adriamycin in rats

A Nacira 1, K Fatima 2, K Wahiba 1, I Safia 1, B Cherifa 3, K Zahia 4
  • 1Laboratory of Biology and Environment, Department of Animal Biology, Faculty of Sciences of Nature and Life Mentouri – University, Chaabet Ersas Campus, 25000 Constantine, Algeria.
  • 2Laboratory of Animal Biology, Department of Animal Biology, Faculty of Sciences of Nature and Life Mentouri – University, 25000 Constantine, Algeria.
  • 3Laboratory of biochemistry, CHU Mentouri university, Constantine, Algeria.
  • 4Laboratory of Therapeutic Substances, Department of Chemistry, Faculty of Sciences, Mentouri university, Chaabet Ersas Campus, 25000 Constantine, Algeria

Adriamycin (ADR) is an efficient chemotherapeutic agent used against several types of tumors; however, its use is limited due to severe cardiotoxicity. Since it is accepted that ADR induced myocardiopathy is the consequence of Oxidative stress through the mediation of free radicals. The aim of this study was to investigate the effect of Globularia alypum L. butanolic extract on the acute cardiac toxicity induced by ADR in rats.

GABE represent a significant source of phenolic compounds. It has been recognized that polyphenols and flavonoids show antioxidant activity.

Oxidative stress in the heart tissue was estimated by measuring the glutathione (GSH) levels homogenate and malondialdehyde (MDA) in the cardiac cytosolic fraction. The pretreatment of rats with the GABE orally at a dose of 100mg/kg for one month resulted in a decrease in cardiac cytosolic MDA and a maintenance of cardiac cytosolic GSH level as compared to ADR treated animals at a dose of 20mg/kg intraperitoneally.

In this study we have investigated the cardioprotective effect of GABE against ADR induced acute cardiotoxicity. We report here that the pretreatment of GABE is able to reduce the ADR induced acute cardiotoxic manifestations in GSH, MDA. Analytical chemical study revealed that GABE contains phenolics and flavonoids, which are responsible for its potent antioxidant activity. Our studies have shown that ADR induced considerable increase in lipid peroxidation

In conclusion, the present study shows that chronic administration of butanolic fraction of Globularia alypum has cardioprotective potential against ADR induced cardiotoxicity.

Keywords: Adriamycin, Globularia alypum, Cardiotoxicity, Antioxidants, Lipid peroxidation, Histopathology