Subscribe to RSS
Effect of Matricaria chamomilla L. extract on fetal absorption, placenta structure and liver of diabetic pregnant rats.
Diabetes mellitus (DM) results in severe metabolic imbalances and pathological changes in many tissues (1). Diabetes was induced by Streptozotocin in this research. Mating condition was prepared by putting male rats and diabetic female rats together and vaginal plaque was as a positive sign of pregnancy and treatment started with three doses:100,300,500, mg/kg chamomile extract extract or vehicle from 1th to 17th day of gestation by gastric gavages. Blood glucose was measured during 17 days. At 17th day, rats were scarified. The fetuses were released from the yolk sacs and surrounding deciduas and were examined for absorption rate.
Results shows that level of blood glucose was reduced about 1.62 fold (p<0.00) in compassion to vehicle treated diabetic rat group.
In diabetic group that received no treatment feta's spontaneous abortion was 15%. Percentage of absorbed fetuses in chamomile groups received 100,300,500 doses and control group were 0%,2%,0% and 0%respectively. the percentage of absorptions was significantly elevated in vehicle-treated diabetic rats, in comparison with vehicle treated healthy rats and treated diabetic rats. Treatment with Matricaria chamomilla L. significantly reduced re-absorption rates in diabetic rats. also in placetas cause reduction of defects such as Artesia and immature trophoblast in treated diabetic rats.
In the Diabetic group, all signs, such as separated necrosis of hepatocytes, anarchism of liver plates, and lymphocytic inflammation were improved.
Matricaria chamomilla was found to have protective effects on spontaneous abortion and histopathological changes of placenta and liver associated with STZ diabetes in chammomile treated pregnant female rats.
Keywords: Matricaria chamomilla, fetal absorption, placenta, liver, diabetes, pregnancy Ultrastructure, STZ
Acknowledgement: this project was a joint project between Ahvaz Jundishapur University of Medical Sciences and Pharmaceutical Research Network.
References: Aynes JW et al (1996) Curr Opin Endocrinol 3: 227–284.