Planta Med 2011; 77 - PM162
DOI: 10.1055/s-0031-1282920

Chemical composition, antioxidant and antimicrobial activities of the lichen Toninia candida (Weber) Th. Fr (Catillariaceae)

N Manojlovic 1, P Maškovic 2, I Manojlovic 3, P Vasiljevic 4, G Bogdanovic Dusanovic 5, M Juskovic 6, M Aleksic 6, A Zabar 6
  • 1Department of Pharmacy, Medical Faculty, University of Kragujevac, 34000 Kragujevac, Serbia
  • 2Faculty of Agronomy, University of Kragujevac, Cara Dušana 34, 32 000 Čačak, Serbia
  • 3Faculty of Science, Radoja Domanovica 12, University of Kragujevac, 34 000 Kragujevac, Serbia
  • 4Department of Biology, Faculty of Science, University of Nis, Visegradska 33, Nis, Serbia
  • 5College of Applied Professional Studies, 17000 Vranje, Serbia
  • 6Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, 18000 Niš, Serbia

In the present investigation, methanol, chloroform and petroleum ether extracts of the lichen Toninia candida (Weber) Th.Fr. were assayed for their antioxidant and antimicrobial activities. The phenolic composition of the extracts was determined by HPLC-UV analysis. The predominant phenolic compound in all the extracts was the depsidone norstictic acid. Apart from the norstictic acid, the tested extracts of T. candida contain different amounts and ratios of atranorin and stictic, protocetraric and usnic acids. The lichen extracts showed comparable and strong antioxidant activity, exhibited higher DPPH and hydroxyl radical scavenging capacity, chelating activity and inhibitory activity towards lipid peroxidation. The lichen extracts demonstrated major antimicrobial activity against 8 strains with MIC values ranging from 16.62 to 62.50µg/ml. This is the first report of the chemical composition, antioxidant and antimicrobial activities of the lichen Toninia candida.

Keywords: Toninia candida, HPLC-UV, chemical composition, antioxidant activity, antimicrobial activity

Acknowledgement: This work was supported by the Serbian Ministry of Science and the Environment, Project No. 172015