Wound healing and anti-inflammatory activities of the Michauxia L'Hérit (Campanulaceae) species native to Turkey

Michauxia L'Hérit (Campanulaceae) species are used as vegetable and medicinal plants in Turkey, and five species of this genus grow naturally in Turkey. The leaf of M. campanuloides L'Hérit ex Aiton is used in traditional medicine the treatment of wounds in Kahramanmaraş (Turkey). The present study was designed to investigate the wound healing and anti-inflammatory activities of the water and methanol (MeOH) extracts obtained from the root and herb of five Michauxia species. The incision by using tensiometer and excision models were used in order to assess the effect of the plant extracts on wound healing in mice and rats. Results were also evaluated histopathologically. In vivo inhibitory effect of the extracts on acetic acid-induced increase in capillary permeability was studied for the assessment of anti-inflammatory activity. The wound healing effect was comparatively evaluated with a reference ointment Madecassol®. Noteworthy wound healing activity was observed for the ointment formulation prepared with 1% M. nuda A.DC. (root MeOH) and M. tchihatchewii Fisch. et Mey. (herba MeOH) extracts. The results of histopathological evaluation supported the outcome of both incision and excision wound models. Moreover, the root extract of the M. nuda exerted remarkable anti-inflammatory activity also demonstrated. The experimental study revealed that Mictauxia displays remarkable wound healing and anti-inflammatory activities.

Keywords: Michauxia, wound healing