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DOI: 10.1055/s-0031-1282886
In vitro anticariogenic effects of polyphenolics from Potentilla recta
Most pharmacological studies have confirmed the traditional use of Potentilla species in many diseases. These pharmacological effects of Potentilla species can be explained by the high amount of polyphenolic compounds present in all plant parts [1,2]. Potentilla recta L. (sulfur cinquefoil) is a long-lived invasive perennial plant from Eurasia that has become one of the most serious invaders of natural area grasslands in North America and Canada. It has been reported to contain 2-pyrone-4,6-dicarboxylic acid, which seems to be a chemotaxonomic marker for the Potentilla species. Ranges of seasonal changes in the content of chlorophyll, carotenoids, free organic, ascorbic and triterpenic acids, neutral triterpenoids and fat oils in some organs and overground phytomass of P. recta have also been determined. More recently, from the aerial parts of P. recta, ten compounds including a neolignan glycoside and flavonol derivatives have been isolated [3,4]. The purpose of the current study was to investigate in vitro the antibacterial activity (by determination of the MICs) of selected polyphenolic compounds: methyl brevifolincarboxylate (I), tiliroside (kaempferol 3-O-β-D-(6“-E-p-coumaroyl)-glucopyranoside) (II), ellagic acid 3, 3'-di-O-methyl ether 4-O-β-D-xylopyranoside (III), apigenin 7-O-β-D-glucopyranoside (III) as well as luteolin 7-O-β-D-glucopyranoside (IV) against cariogenic Streptococcus spp. strains (S. mutans CAPM 6067, S. sobrinus CAPM 6070, S. sobrinus GCM 20381 and S. sobrinus/downei CCUG 21020). MIC values the tested substances were above 400µg/mL (MIC>400µg/mL). Chlorhexidine was used as positive control. In addition their inhibitory effects on insoluble glucan (mutan) and artificial dental plaque formation were also determined [3].
Keywords: Potentilla recta, polyphenolic compounds, anticariogenic activity
Acknowledgement: This study is financially supported by the Polish Ministry of Science and Higher Education (Grant No. N N405 621638)
References: 1. Tomczyk M, Latté KP (2009)J Ethnopharmacol 122: 184–204.
2. Tomczyk M, Pleszczyńska M, Wiater A (2010) Molecules 15: 4639–4651.
3. Tomczyk M, Wiater A, Pleszczyńska M (2011) Phytother Res 25: 343–350.
4. Şöhretoğlu D, Kırmızıbekmez H (2011) Biochem Syst Ecol 39: 132–134.