Planta Med 2011; 77 - PM51
DOI: 10.1055/s-0031-1282809

Chemical Constituents and pharmacological activities of Zilla spinosa

SA El Toumy 1, F El Sharabasy 2, H Ghanem 3, M El Kady 4, A Kassem 2
  • 1Chemistry of Tannins Department, National Research Center, 12622 Dokki, Cairo, Egypt
  • 2Chemistry of Natural and Microbial Department, National Research Center, 12622 Dokki, Cairo, Egypt
  • 3Therapeutic Chemistry Department, National Research Center, 12622 Dokki, Cairo, Egypt
  • 4Department, Faculty of Science, Ain Shams University, Cairo, Egypt

Zilla spinosa T.Durand & Schinz is very wildely distributed in the Egyptian deserts, it is used by the natives for the treatment of the kidney stones. The present study deals with the isolation and identification of chemical constituents of the aerial parts of Zilla spinosa and evaluation of pharmacological activities of its extract. Chemical investigation of the n-hexane and methanolic extract of the aerial parts of Zilla spinosa lead to the isolation of campesterol, spinasterol, β-Sitosterol, α-amyrine, β-amyrine, squalene as well as quercetin 3-O-α-rhamnopyranoside (6→1) β- glucopyranoside, kaempferol 3-O-α-rhamnopyranoside(6→1) β-glucopyranoside, quercetin 3-O- β- glucopyranosid, kaempferol 3-O- β- glucopyranoside, quercetin, kaempferol. Structures of the isolated compounds were established by chromatography, UV, HRESI-MS and 1D/2D 1H/13C NMR spectroscopy.The methanolic extract showed potent analgesic, anti-inflammatory and hepatoprotective activities.

Keywords: Zilla spinosa, Flavonoids, hepatoprotective, analgesic, anti-inflammatory