Planta Med 2011; 77 - PG91
DOI: 10.1055/s-0031-1282575

New Hexadecan-2-ol and 3-Hydroxymethyloctadecanoate with Hepatoprotective Activity and Cytotoxicity Activity from Grindelia camporum Greene (Asteraceae)

AM El Moghazy 1, FM Darwish 1, ES El Khayat 2, MO Mohamed 2, M Wink 3, MZ El Readi 4
  • 1Pharmacognosy Dept., Faculty of Pharmacy, Assiut University, Assiut, Egypt
  • 2Pharmacognosy Dept., Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
  • 3Biology Dept., Institute of Pharmacy and Molecular Biotechnology (IPMB), University of Heidelberg, Germany
  • 4Biochemistry Dept., Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

New hexadecan-2-ol (8) and 3-hydroxymethyloctadecanoate (10), together with 14 known compounds (1–7, 9, 11–16) have been isolated from Grindelia camporum Greene var. camporum. The new compounds were characterized through spectroscopic studies including 1D (1H and 13C NMR) and 2D (COSY, HSQC and HMBC) NMR and mass spectroscopy. The known compounds (Compounds 3 and 4 are hitherto unreported from the family Asteraceae) were identified by comparison of their spectral data with those reported in the literature, chemical evidence or authentic samples [1–3]. The total methanolic extract and the total aqueous extract exhibited cytotoxic and hepatoprotective activities respectively. Also antimicrobial, toxicological (LD50, anti-inflammatory, antipyretic and analgesic activities of the different fractions were studied [4–6].

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6-Achliya GS et al. (2003) Ind J Pharmacol 35: 308–311.