New Hexadecan-2-ol and 3-Hydroxymethyloctadecanoate with Hepatoprotective Activity and Cytotoxicity Activity from Grindelia camporum Greene (Asteraceae)
New hexadecan-2-ol (8) and 3-hydroxymethyloctadecanoate (10), together with 14 known compounds (1–7, 9, 11–16) have been isolated from Grindelia camporum Greene var. camporum. The new compounds were characterized through spectroscopic studies including 1D (1H and 13C NMR) and 2D (COSY, HSQC and HMBC) NMR and mass spectroscopy. The known compounds (Compounds 3 and 4 are hitherto unreported from the family Asteraceae) were identified by comparison of their spectral data with those reported in the literature, chemical evidence or authentic samples [1–3]. The total methanolic extract and the total aqueous extract exhibited cytotoxic and hepatoprotective activities respectively. Also antimicrobial, toxicological (LD50, anti-inflammatory, antipyretic and analgesic activities of the different fractions were studied [4–6].
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